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Wnt Signaling Pathway in Schizophrenia
CNS & Neurological Disorders - Drug Targets, 2014The Wnt signaling pathway is one of the crucial signaling pathways that regulate many aspects of central nervous system. In this review, we tempt to depict an overall picture of the Wnt signaling with its multitude of roles in schizophrenia. If the Wnt signaling pathway plays a crucial role in the pathogenesis of schizophrenia as we suggest, a better ...
Yanmin, Peng, Yifeng, Xu, Donghong, Cui
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Annual Review of Biochemistry, 2022
The Wnt pathway is central to a host of developmental and disease-related processes. The remarkable conservation of this intercellular signaling cascade throughout metazoan lineages indicates that it coevolved with multicellularity to regulate the generation and spatial arrangement of distinct cell types.
Rim, Ellen Youngsoo +2 more
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The Wnt pathway is central to a host of developmental and disease-related processes. The remarkable conservation of this intercellular signaling cascade throughout metazoan lineages indicates that it coevolved with multicellularity to regulate the generation and spatial arrangement of distinct cell types.
Rim, Ellen Youngsoo +2 more
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Frontiers in Bioscience, 2007
Breast cancer is one of the most debilitating human carcinomas with second highest mortality rate after lung cancer in women. Recent advancement in genetic and biochemical analyses has deciphered the molecular pathways involved in breast cancer development. Wnt signal has long been established to play a critical role in normal development as well as in
Sonia, Mohinta +3 more
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Breast cancer is one of the most debilitating human carcinomas with second highest mortality rate after lung cancer in women. Recent advancement in genetic and biochemical analyses has deciphered the molecular pathways involved in breast cancer development. Wnt signal has long been established to play a critical role in normal development as well as in
Sonia, Mohinta +3 more
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Wnt signalling pathway in bladder cancer
Cellular Signalling, 2021Bladder cancer (BC) is one of the most common tumours of the urinary system and is also known as a highly malignant tumour. In addition to conventional diagnosis and treatment methods, recent research has focused on studying the molecular mechanisms related to BC, in the hope that new, less toxic and effective targeted anticancer drugs and new ...
Guanlin, Wu +7 more
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Science, 2004
STKE Frizzled proteins act as receptors for Wnts, secreted proteins that play a critical role in animal development. In Caenorhabditis elegans vulval development, the anterior-posterior orientation of cells of the P7.p lineage is disrupted by mutation of lin-17 (which encodes a Frizzled protein)
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STKE Frizzled proteins act as receptors for Wnts, secreted proteins that play a critical role in animal development. In Caenorhabditis elegans vulval development, the anterior-posterior orientation of cells of the P7.p lineage is disrupted by mutation of lin-17 (which encodes a Frizzled protein)
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Wnt signaling: Sox Enters the Wnt Pathway
Science's STKE, 1999The Wnt signaling pathway regulates numerous cellular responses including those that govern axis formation and dorsal-ventral patterning in the developing Xenopus laevis embryo. Upon binding to its receptor Frizzled, a signaling cascade is triggered that results in β-catenin-dependent transcription of Wnt target ...
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Science Signaling, 2015
Wnt signals through G proteins to activate the transcriptional coregulators YAP and TAZ.
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Wnt signals through G proteins to activate the transcriptional coregulators YAP and TAZ.
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2008
Abstract The Wnt (wingless) signaling pathway is an important signal transduction pathway that is well conserved across animal phyla. Wnts are a large family of secreted signaling molecules known to play important and diverse roles in developmental processes such as cell fate speci7cation, cell migration, and cell proliferation ...
Lorna S Kategaya +2 more
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Abstract The Wnt (wingless) signaling pathway is an important signal transduction pathway that is well conserved across animal phyla. Wnts are a large family of secreted signaling molecules known to play important and diverse roles in developmental processes such as cell fate speci7cation, cell migration, and cell proliferation ...
Lorna S Kategaya +2 more
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Wnt signaling pathway and lung disease
Translational Research, 2008The Wnt pathway plays an important role in development and in regulating adult stem cell systems. A variety of cellular processes is mediated by Wnt signaling, which includes cellular proliferation, differentiation, survival, apoptosis, and cell motility.
Michelle, Van Scoyk +5 more
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Science's STKE, 2005
Wnts are secreted glycoproteins that act as ligands to stimulate receptor-mediated signal transduction pathways in both vertebrates and invertebrates. Activation of Wnt pathways can modulate cell proliferation, survival, cell behavior, and cell fate in both embryos and adults.
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Wnts are secreted glycoproteins that act as ligands to stimulate receptor-mediated signal transduction pathways in both vertebrates and invertebrates. Activation of Wnt pathways can modulate cell proliferation, survival, cell behavior, and cell fate in both embryos and adults.
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