Results 271 to 280 of about 317,971 (305)
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The Wnt Pathway: Emerging Anticancer Strategies
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery, 2013The canonical Wnt cascade has emerged as a critical regulator of cancer cells. Activation of the Wnt signaling pathway has also been associated with stem cell, thus raising the possibility of its role in embryogenesis and in the proliferation of malignant cancer cells.
Aman, Gupta +5 more
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Clinical calcium, 2013
Wnts transduce signals through Wnt/β-catenin pathway (canonical pathway) , in which β-catenin stimulates transcription of target genes, as well as several kinds of non-β-catenin Wnt pathways (alternative pathways) . Wnt/β-catenin pathway is essential for cell proliferation and survival, and its activity is strictly regulated by several antagonists ...
Yuka, Kinoshita, Seiji, Fukumoto
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Wnts transduce signals through Wnt/β-catenin pathway (canonical pathway) , in which β-catenin stimulates transcription of target genes, as well as several kinds of non-β-catenin Wnt pathways (alternative pathways) . Wnt/β-catenin pathway is essential for cell proliferation and survival, and its activity is strictly regulated by several antagonists ...
Yuka, Kinoshita, Seiji, Fukumoto
openaire +1 more source
Dictyostelium Development: A Prototypic Wnt Pathway?
2008Although Wnt signaling is ubiquitous within the animal phylogenetic group, it is unclear how it evolved. Genes related to the components of Wnt pathway are found in other eukaryotes and one of the most studied of these non-metazoan organisms is the social amoeba Dictyostelium discoideum.
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Science's STKE : signal transduction knowledge environment, 2006
Wnts are secreted glycoproteins that act as ligands to stimulate receptor-mediated signal transduction pathways in both vertebrates and invertebrates. Activation of Wnt pathways can modulate cell proliferation, survival, cell behavior, and cell fate in both embryos and adults.
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Wnts are secreted glycoproteins that act as ligands to stimulate receptor-mediated signal transduction pathways in both vertebrates and invertebrates. Activation of Wnt pathways can modulate cell proliferation, survival, cell behavior, and cell fate in both embryos and adults.
openaire +1 more source
Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine
Nature Reviews Drug Discovery, 2020Anwesha Dey +2 more
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Poly(ADP-Ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic
Ca-A Cancer Journal for Clinicians, 2011Timothy A Yap, Johann Sebastian de Bono
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Recent developments in the medical and surgical treatment of melanoma
Ca-A Cancer Journal for Clinicians, 2014Jonathan S Zager
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