Results 71 to 80 of about 317,971 (305)

Wnt/Ca2+ pathway inhibits neural differentiation of human dental pulp stem cells in vitro

Journal of Dental Sciences
Background/purpose: Dental pulp stem cells (DPSCs) have demonstrated significant potential for neuroregeneration. However, a full understanding of the specific mechanism underpinning the neural differentiation of DPSCs is still required.
Shi-Hua Wang, Shi-Rui Wang, Na-Na Luan, Xiao-Qian Sun, Yi-Ran Guo, Ying-Bin Yan, Su-Xia Liang   +6 more
doaj   +1 more source

WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth [PDF]

, 2009
: INTRODUCTION: In breast cancer deregulation of the WNT signaling pathway occurs by autocrine mechanisms. WNT ligands and Frizzled (FZD) receptors are coexpressed in primary breast tumors and cancer cell lines.
Yutaka Matsuda, Thomas Schlange, Edward J Oakeley, Anne Boulay, Nancy E Hynes, H Clevers, R van Amerongen, LR Howe, M Katoh, EL Huguet, A Bafico, T Schlange, T Milovanovic, A Ayyanan, F Ugolini, J Veeck, E Klopocki, N Li, H Hashizume, RM Neve, JS Lee, JM Gonzalez-Sancho, GP Gupta, AJ Minn, J Ezan, M Shtutman, O Tetsu, TC He, T Reya, S Wu, F Takahashi-Yanaga, R Nusse, VI DeAlmeida, M Shulewitz, X Zi, F Ugolini, GM Caldwell, T Takada, CJ Marsit, D Lodygin, MT Chung, YY Cheng, R Habas, Y Endo, C Jones, ES Witze, J Vervoorts, N Meyer, S Han   +48 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Wnt Signaling in Atherosclerosis: Mechanisms to Therapeutic Implications

Biomedicines
Atherosclerosis is a vascular disease in which inflammation plays a pivotal role. Receptor-mediated signaling pathways regulate vascular inflammation and the pathophysiology of atherosclerosis.
Rizwana Afroz, Julie E. Goodwin
doaj   +1 more source

Down-regulation of the canonical Wnt β-catenin pathway in the airway epithelium of healthy smokers and smokers with COPD.

PLoS ONE, 2011
BackgroundThe Wnt pathway mediates differentiation of epithelial tissues; depending on the tissue types, Wnt can either drive or inhibit the differentiation process.
Rui Wang, Joumana Ahmed, Guoqing Wang, Ibrahim Hassan, Yael Strulovici-Barel, Neil R Hackett, Ronald G Crystal   +6 more
doaj   +1 more source

Photoperiodic and diurnal regulation of WNT signalling in the arcuate nucleus of the 1 female Djungarian hamster, Phodopus sungorus [PDF]

, 2015
yesThe WNT pathway was shown to play an important role in the adult central nervous system. We previously identified the WNT pathway as a novel integration site of the adipokine leptin in mediating its neuroendocrine control of metabolism in obese mice ...
Abarzua, Alexander Tups, Alisa Boucsein, Asher, Benzler, Benzler, Bjorbaek, Boutros, Caricasole, Cerpa, Cindy Hempp, Ding, Ellis, Fu, Gisela Helfer, Guo, Hakansson, Hall, Harada, Hatanaka, Helfer, Helfer, Hirabayashi, Hoang, Horton, Inestrosa, Jho, Jonas Benzler, Klingenspor, Ko, Krupnik, Ladher, Lahti, Lamia, Lescher, Lyons, Lyuksyutova, MacDonald, Mao, Mao, Mercer, Mercer, Mercer, Moon, Ohba, Paxinos, Peifer, Quelle, Rattner, Reppert, Ross, Ross, Sahar, Shioda, Sigrid Stöhr, Slusarski, Spengler, Stenman, Tamai, Tamai, Tan, Tetsu, Tolwinski, Tsuji, Tups, Tups, Tups, Tups, Ueno, Yin, Yoshino   +70 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Novel recombinant R-spondin1 promotes hair regeneration by targeting the Wnt/β-catenin signaling pathway

Acta Biochimica et Biophysica Sinica, 2023
Roof plate-specific spondin 1 (R-spondin1, RSPO1) is a Wnt/β-catenin signaling pathway activator that binds with Wnt ligands to stimulate the Wnt/β-catenin signaling pathway, which is key to hair regeneration. However, it is not clear whether recombinant
Chen Yijun, Lu Zhujin, Feng Jiaxin, Chen Zefeng, Liu Zejian, Wang Xiuqi, Yan Huichao, Gao Chunqi   +7 more
doaj   +1 more source

Anomalous vascularization in a Wnt medulloblastoma: A case report [PDF]

, 2016
BACKGROUND: Medulloblastoma is the most common malignant brain tumor in children. To date only few cases of medulloblastoma with hemorrhages have been reported in the literature.
Cacchione, Antonella, Carai, Andrea, Colafati, Giovanna Stefania, Dell'Anna, Vito Andrea, Di Giannatale, Angela, Diomedi Camassei, Francesca, Ferretti, Elisabetta, Locatelli, Franco, Marrazzo, Antonio, Mastronuzzi, Angela, Miele, Evelina, Po, Agnese   +11 more
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source