Results 101 to 110 of about 259,205 (374)
FEBS Open Bio, EarlyView.The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli +15 more
wiley +1 more source
Mutational analysis of dishevelled genes in zebrafish reveals distinct functions in embryonic patterning and gastrulation cell movements. [PDF]
PLoS Genetics, 2018 Wnt signaling plays critical roles in dorsoventral fate specification and anteroposterior patterning, as well as in morphogenetic cell movements. Dishevelled proteins, or Dvls, mediate the activation of Wnt/ß-catenin and Wnt/planar cell polarity pathways.
Yan-Yi Xing +7 more
doaj +1 more source
Membrane targeting of palmitoylated Wnt and Hedgehog revealed by chemical probes [PDF]
, 2011 Palmitoylation of the Wnt and Hedgehog proteins is critical for maintaining their physiological functions. To date, there are no reported studies that characterize the cellular distribution of the palmitoylated forms of these proteins.
Arenas-Ramirez, Natalia +3 more
core +1 more source
Biochemical characterization of Wnt-Frizzled interactions using a soluble, biologically active vertebrate Wnt protein [PDF]
Proceedings of the National Academy of Sciences, 1999 Biochemical studies of Wnt signaling have been hampered by difficulties in obtaining large quantities of soluble, biologically active Wnt proteins. In this paper, we report the production in Drosophila S2 cells of biologically active Xenopus Wnt8 (XWnt8).
Amir Rattner +3 more
openaire +3 more sources
FEBS Open Bio, EarlyView.Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran +3 more
wiley +1 more source
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
Signal Transduction and Targeted Therapy, 2022 The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer
Jiaqi Liu +8 more
doaj +1 more source
A quantitative study on the role of TKI combined with Wnt/$β$-catenin signaling and IFN-$α$ in the treatment of CML through deterministic and stochastic approaches [PDF]
, 2019 We propose deterministic and stochastic models for studying the pharmacokinetics of chronic myeloid leukemia (CML), upon administration of IFN-$\alpha$ (the traditional treatment for CML), TKI (the current frontline medication for CML) and Wnt/$\beta$-catenin signaling (the state-of-the art therapeutic breakthrough for CML).
arxiv +1 more source
Equilibria decomposition-based comparison of reaction networks of Wnt signaling [PDF]
arXiv, 2023 The Wnt signaling pathway plays a critical role in various biochemical processes, including embryonic development, tissue homeostasis, and cancer progression. In this paper, we conduct a comparative analysis of $\beta$-catenin-dependent Wnt signaling reaction networks, which we refer to as the Feinberg, Schmitz, and MacLean models, based on the ...
arxiv
The role of circular RNAs in regulating cytokine signaling in cancer
FEBS Open Bio, EarlyView.Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi +4 more
wiley +1 more source
Primary cilia are not required for normal canonical Wnt signaling in the mouse embryo. [PDF]
PLoS ONE, 2009 Sonic hedgehog (Shh) signaling in the mouse requires the microtubule-based organelle, the primary cilium. The primary cilium is assembled and maintained through the process of intraflagellar transport (IFT) and the response to Shh is blocked in mouse ...
Polloneal Jymmiel R Ocbina +2 more
doaj +1 more source