Results 121 to 130 of about 176,136 (293)

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

Advanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian, Jing Zhu, Jianhong Wu, Yan Zhang, Jianghua Chen, Huan Wang, Hengyan Liu, Ke Xu, Jiaxin Huang, Xiaoting Zhu, Yuanli Wei, Shilin Li, Tingting Wang, Xuan Huang, Qinghua Zou, Jie Zhang, Jiang Su, Xinming Du, Yaping Lu, Tianci Zhou, Yingtong Zhou, Minglong Tang, Bin Li, Xue Zhou, Qihao Wei, Qiulong Yan, Fanxin Zeng   +26 more
wiley   +1 more source

Protein Wnt-7a [PDF]

, 2020
openaire   +1 more source

ROS Activated NETosis of Bone Marrow CD55+ Intermediate Mature Neutrophils Through HIF1α‐PADI4 Pathway to Initiate Bone Aging

Advanced Science, EarlyView.
In this study, we find CD55+ neutrophils show activated NETosis within bone marrow, induce BMSC senescence and osteogenesis inhibition, finally leading to bone aging initiation. Mechanistically, ROS synergizes with the CD55‐driven HIF1α‐PADI4 pathway to promote NETosis.
Yutong Guo, Shengjie Cui, Xi Wen, Yidi Wang, Ben Wu, Yixiang Wang, Yan Gu   +6 more
wiley   +1 more source

Association between Wnt inhibitory factor 1 and receptor tyrosine kinase-like orphan receptor 2 protein expression and the clinical pathological significance in benign and malignant pancreatic lesions

, 2017
Daoqi Zhu, Zhulin Yang, Ziru Liu, Qiong Zou, Yuan Yuan, Chunhong Hu   +5 more
openalex   +2 more sources

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

G protein subunit gamma 5 promotes the proliferation, metastasis and glycolysis of breast cancer cells through the Wnt/β-catenin pathway

, 2022
Zuguo Yuan, Ruiping Ren, Zhengyang Xu
openalex   +2 more sources

Bisphenol B Exposure Induces Miscarriage by Suppressing Migration/Invasion and Migrasome Formation

Advanced Science, EarlyView.
BPB (Bisphenol B) exposure up‐regulates ER (estrogen receptor) levels, enhances its interactions with the lnc‐HZ04 promoter region, and thus promotes ER‐mediated lnc‐HZ04 transcription. Subsequently, lnc‐HZ04 suppresses TCF4 (transcription factor 4)‐mediated PKCA (protein kinase C alpha) transcription and subsequently suppresses migration/invasion and ...
Wenxin Huang, Manli Wang, Yi Sun, Xiaoping Yue, Xun Li, Yanbing Lin, Geng Guo, Depeng Zhao, Qigang Fan, Xiaoling Ma, Zhihong Zhang, Shuaishuai Xing, Xiaoting Shen, Huidong Zhang   +13 more
wiley   +1 more source

Analiza gena i proteina signalnih puteva Wnt i Sonic Hedgehog u primarnoj i sekundarnoj mijelofibrozi [Analysis of genes and proteins of WNT and Sonic Hedgehog signaling pathways in primary and secondary myelofibrosis] [PDF]

, 2017
Marko Lucijanić
openalex  

Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt–β-catenin and Wnt–RhoA–Rac1 pathways [PDF]

, 2009
Vinicio A. de Jesús Pérez, Tero-Pekka Alastalo, Jenny Wu, Jeffrey D. Axelrod, John P. Cooke, Manuel R. Amieva, Marlene Rabinovitch   +6 more
openalex   +1 more source

WNT Family Protein [PDF]

, 2020
openaire   +1 more source