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A new secreted protein that binds to Wnt proteins and inhibits their activites [PDF]
Nature, 1999 The Wnt proteins constitute a large family of extracellular signalling molecules that are found throughout the animal kingdom and are important for a wide variety of normal and pathological developmental processes. Here we describe Wnt-inhibitory factor-1 (WIF-1), a secreted protein that binds to Wnt proteins and inhibits their activities.
Cindy Harryman Samos +8 more
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Journal of Cell Science, 1999
ABSTRACT The Wnt gene family encodes proteins that serve key roles in differentiation and development. Wnt proteins interact with seven transmembrane receptors of the Frizzled family and activate a signaling pathway leading to the nucleus. A primary biochemical effect of Wnt-1 signaling is the stabilization of cytoplasmic β-catenin which,
J. Papkoff +4 more
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ABSTRACT The Wnt gene family encodes proteins that serve key roles in differentiation and development. Wnt proteins interact with seven transmembrane receptors of the Frizzled family and activate a signaling pathway leading to the nucleus. A primary biochemical effect of Wnt-1 signaling is the stabilization of cytoplasmic β-catenin which,
J. Papkoff +4 more
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Retrograde signalling at the synapse: a role for Wnt proteins
Biochemical Society Transactions, 2005The formation of functional synapses requires a proper dialogue between incoming axons and their future synaptic targets. As axons approach their target, they are instructed to slow down and remodel to form proper presynaptic terminals. Although significant progress has been made in the identification of the mechanisms that control axon guidance ...
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Isolation and Application of Bioactive Wnt Proteins
2008Wnt proteins and their signaling cascades are involved in a wide variety of developmental processes, and deregulation of this pathway is frequently associated with tumorigenesis. Unlike many other growth factors, Wnts long eluded biochemical purification, in large part because of their hydrophobic nature, which is imparted by one or more lipid ...
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Wnt signalling: the case of the ‘missing’ G-protein
Biochemical Journal, 2011Wnt signalling remains a hot topic for cell signalling sleuthhounds. The trail of signalling downstream of the seven-transmembrane segment Frizzleds, which bind Wnt ligands, is replete of clues [e.g. LPR5/6 (lipoprotein receptor-related protein 5/6), G-proteins or Dishevelled] and yet remains the ‘final problem’.
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Wnt Proteins in Mineralized Tissue Development and Homeostasis
Connective Tissue Research, 2011The past decade has seen rapid advancement in the dissection of the molecular events and players in the development and homeostasis of mineralized tissues, that is, teeth and bones. Much of this is due to research efforts toward the regeneration of these organs and also to develop treatments for pathologies of bone, especially osteoporosis.
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Proteomic Analyses of Protein Complexes in the Wnt Pathway
2008Multiple screens performed in Drosophila, Caenorhabditis elegans, Xenopus, and zebrafish have identified dozens of proteins participating in Wnt signal transduction. Epistasis experiments, enhancer and suppressor screens, and protein-protein interaction techniques have also been efficient at finding new pathway members, connecting proteins together ...
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Nanooncology: The future of cancer diagnosis and therapy
Ca-A Cancer Journal for Clinicians, 2013Avnesh S Thakor
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MicroRNAome genome: A treasure for cancer diagnosis and therapy
Ca-A Cancer Journal for Clinicians, 2014Ioana Berindan-neagoe +2 more
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