Results 241 to 250 of about 176,136 (293)

A Biomimetic Norepinephrine‐Loaded Aligned Mineralized Collagen Scaffold for Coordinated Neurovascular, Osteogenic, and Immunomodulatory Repair of Critical‐Sized Bone Defects

Advanced Science, EarlyView.
Inspired by the composition and structure of native bone tissue and its complex interplay of biological signals, a norepinephrine‐loaded biomimetic mineralized electrocompacted collagen scaffold (NE‐MEC) is developed capable of simultaneously supporting osteogenesis, neural repair, angiogenesis, and immune modulation.
Zhengyun Ren, Zhaojun Wu, Anhang Wu, Hui Zhang, Jiachen Lu, Jiahao Zhang, Jie Weng, Jinhua Zhang, Song Chen, Huan Tan, Tailin Guo   +10 more
wiley   +1 more source

Influence of pigment epithelium-derived factors on H₂O₂-induced oxidative damage and melanin synthesis in Melan-a cells. [PDF]

Biol Res
Cui Y, Ye F, Hou Z, Li G, Li L, Zhao H, Hu D, Yin Z, Chen L, Ning H, Ge Y, Pang Q.   +11 more
europepmc   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

The Actin regulator Mena promotes Wnt signalosome endocytosis and Wnt signalling

Wu S, Moreno MM, Noble A, Azwan AH, Guille M, Liu KJ, Krause M.   +6 more
europepmc   +1 more source

Localized Wnt-signaling promotes asymmetric NuMA-dependent oriented divisions and unequal apportioning of mitochondria. [PDF]

Nat Commun
Eli S, Rauso G, Ghezzi P, Szczerkowski JLA, Bruzzi M, Rizzelli F, Iommazzo F, Loffreda A, Castagna F, Donà F, Gaddoni C, Dondi A, Marenda M, Rodighiero S, Tournier P, Lavagnino Z, Parazzoli D, Gauthier NC, Tamburri S, Pasini D, Habib SJ, Mapelli M.   +21 more
europepmc   +1 more source

Identification of a Force‐Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2–FGFR2–ERK Signaling in Orthodontic Bone Remodeling

Advanced Science, EarlyView.
Mechanical loading induces a previously unrecognized Sox9+Acan+ transitional mesenchymal cell population in the periodontal ligament that promotes osteoclastogenesis via the FGF2–FGFR2–ERK axis. Targeting this mechanoresponsive stromal population using a localized GelMA@siRNA delivery strategy attenuates pathological osteoclast overactivation and root ...
Miao Tan, Minyu He, Mingrui Zong, Qiya Tang, Yinan Liu, Jiaju Deng, Shun Huang, Xiaoxiao Lei, Jie Li, Lan Huang   +9 more
wiley   +1 more source

Assessment of miRNA 106a-5p and 375-3p Expression in the Context of the Wnt/β-Catenin Pathway-Comparison of Prostate Adenocarcinoma and Benign Prostatic Hyperplasia Tissues. [PDF]

Int J Mol Sci
Smereczańska M, Domian N, Młynarczyk G, Kasacka I.   +3 more
europepmc   +1 more source

Nitrogen‐Boosted H2O2 Production of Arginine‐Polyphenol Nanozyme Drives Oxidative Eustress for Hair Regeneration

Advanced Science, EarlyView.
PEA nanoenzymes are assembled from L‐arginine and EGCG. The nitrogen element in arginine enhances the thermodynamic feasibility of H2O2 production through PEA's oxygen reduction catalysis, enabling nitrogen‐dependent H2O2 release. Intradermal delivery of PEA via microneedles promotes efficient H2O2 synthesis, thereby stimulating regrowth in telogen ...
Yifei Wang, Yaojia Yang, Aoxue Wang, Chen Shen, Shenliang Tan, Changsheng Liu, Yuzheng Zhao, Xue Qu   +7 more
wiley   +1 more source

Microbial metabolite trimethylamine-N-oxide facilitates colorectal inflammation-cancer transformation by blocking lysosomal degradation of Wnt signaling. [PDF]

Gut Microbes
Yang K, Liu Z, Wang H, Xiao Z, Zhao W, Gong W.   +5 more
europepmc   +1 more source

Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1+ Macrophages to Foster Liver Metastasis, Targeted by Indole‐3‐Acetic Acid

Advanced Science, EarlyView.
Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang, Shipeng Dai, Yuchen Xie, Pengyu Chen, Yue Chai, Chongyu Wang, Xueying Huang, Xiao Dong, Junfeng Shi, Yongxiang Xia, Xiaofeng Qian, Weiwei Tang, Yichan Zhou   +12 more
wiley   +1 more source