Results 41 to 50 of about 176,136 (293)

Soluble Frizzled-related proteins promote exosome-mediated Wnt re-secretion

Communications Biology
Wnt proteins are thought to be transported in several ways in the extracellular space. For instance, they are known to be carried by exosomes and by Wnt-carrier proteins, such as sFRP proteins.
Thi Hong Nguyen Tran, Ritsuko Takada, Elena Krayukhina, Takahiro Maruno, Yusuke Mii, Susumu Uchiyama, Shinji Takada   +6 more
doaj   +1 more source

HDAC1 regulates inflammation and osteogenic differentiation of ankylosing spondylitis fibroblasts through the Wnt-Smad signaling pathway

Journal of Orthopaedic Surgery and Research, 2022
Ankylosing spondylitis (AS) is a refractory autoimmune disease, whose typical pathology is the development of inflammation to ossification and ankylosis.
Yong Zeng, Rui He, Yong Liu, Ting Luo, Qing Li, Yu He, Miao Fang, Taiping Wang   +7 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Novel recombinant R-spondin1 promotes hair regeneration by targeting the Wnt/β-catenin signaling pathway

Acta Biochimica et Biophysica Sinica, 2023
Roof plate-specific spondin 1 (R-spondin1, RSPO1) is a Wnt/β-catenin signaling pathway activator that binds with Wnt ligands to stimulate the Wnt/β-catenin signaling pathway, which is key to hair regeneration. However, it is not clear whether recombinant
Chen Yijun, Lu Zhujin, Feng Jiaxin, Chen Zefeng, Liu Zejian, Wang Xiuqi, Yan Huichao, Gao Chunqi   +7 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling

eLife, 2015
Wnt signaling is essential for tissue homeostasis and its dysregulation causes cancer. Wnt ligands trigger signaling by activating Frizzled receptors (FZDRs), which belong to the G-protein coupled receptor superfamily.
Nicolas Aznar, Krishna K Midde, Ying Dunkel, Inmaculada Lopez-Sanchez, Yelena Pavlova, Arthur Marivin, Jorge Barbazán, Fiona Murray, Ulrich Nitsche, Klaus-Peter Janssen, Karl Willert, Ajay Goel, Miguel Abal, Mikel Garcia-Marcos, Pradipta Ghosh   +14 more
doaj   +1 more source

The Wnt/β-catenin signalling pathway in Haematological Neoplasms

Biomarker Research, 2022
Leukaemia and lymphoma are common malignancies. The Wnt pathway is a complex network of proteins regulating cell proliferation and differentiation, as well as cancer development, and is divided into the Wnt/β-catenin signalling pathway (the canonical Wnt
Siwei Yu, Ruyue Han, Runliang Gan
doaj   +1 more source

Wnt proteins synergize to activate β-catenin signaling [PDF]

Journal of Cell Science, 2017
ABSTRACT Wnt ligands are involved in diverse signaling pathways that are active during development, maintenance of tissue homeostasis and in various disease states. While signaling regulated by individual Wnts has been extensively studied, Wnts are rarely expressed alone, and the consequences of Wnt gene co-expression are not well ...
Anshula Alok, Zhengdeng Lei, N. Suhas Jagannathan, Simran Kaur, Nathan Harmston, Steven G. Rozen, Lisa Tucker-Kellogg, David M. Virshup   +7 more
openaire   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Alternative splicing of the Wnt trafficking protein, Wntless and its effects on protein-protein interactions

BMC Molecular and Cell Biology, 2019
Background Wntless (Wls) is a protein that regulates secretion of Wnt signaling molecules from Wnt-producing cells. Wnt signaling is known to be critical for several developmental and homeostatic processes.
Jessica Petko, Mathura Thileepan, Molly Sargen, Victor Canfield, Robert Levenson   +4 more
doaj   +1 more source