Results 71 to 80 of about 1,026,340 (233)

Leading Wnt down a PCP Path: Cthrc1 Acts as a Coreceptor in the Wnt-PCP Pathway [PDF]

, 2008
Wnt signaling regulates many aspects of development through canonical and PCP signaling pathways. A paper by Yamamoto et al. in this issue of Developmental Cell identifies collagen triple helix repeat containing 1 as a Wnt-binding cofactor that ...
Kelley, Matthew W.
core   +1 more source

Tumor promoter TPA activates Wnt/β-catenin signaling in a casein kinase 1-dependent manner. [PDF]

, 2018
The tumor promoter 12-O-tetra-decanoylphorbol-13-acetate (TPA) has been defined by its ability to promote tumorigenesis on carcinogen-initiated mouse skin.
Carson, Dennis A, Li, Shiyue, Liu, Shan-Shan, Lu, Desheng, Song, Jiaxing, Su, Zijie, Sun, Qi, Wang, Zhongyuan, Wei, Lei, Xia, Yuqing, Yu, Shubin, Zhao, Liang, Zhou, Liang   +12 more
core  

Subtle deregulation of the Wnt-signalling pathway through loss of Apc2 reduces the fitness of intestinal stem cells [PDF]

, 2018
The importance of the Wnt-signaling pathway on the regulation and maintenance of the intesti- nal stem cell (ISC) population is well recognized. However, our current knowledge base is founded on models using systems of gross deregulation of the Wnt ...
Clarke, Alan, Daly, Carl, James, Rhiannon, Reed, Karen, Taylor, Elaine, Young, Madeleine   +5 more
core   +1 more source

Wnt signaling pathway in retinal vascularization

Eye and Brain, 2016
Wnt-signaling, a ubiquitous pathway that directs differentiation, cell polarity, and tissue specificity, has been implicated as an important gene-expression pathway in retinal development.
K. Drenser
semanticscholar   +1 more source

The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspective

Cell & Bioscience, 2012
The Wnt signaling pathway was initially discovered for its role in tumorigenesis and the development of Drosophila and other eukaryotic organisms. The key effector of this pathway, the bipartite transcription factor β-cat/TCF, is formed by free β-catenin
Ip Wilfred, Chiang Yu-ting, Jin Tianru
doaj   +1 more source

Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis. [PDF]

, 2019
Neural crest (NC) cells are a temporary population of multipotent stem cells that generate a diverse array of cell types, including craniofacial bone and cartilage, smooth muscle cells, melanocytes, and peripheral neurons and glia during embryonic ...
Hao, Hongyan, Ji, Yu, McMahon, Moira, Reynolds, Kurt, Zhou, Chengji J   +4 more
core   +2 more sources

Wnt/β-catenin signaling stimulates the expression and synaptic clustering of the autism-associated Neuroligin 3 gene [PDF]

, 2018
Indexación: Scopus.Synaptic abnormalities have been described in individuals with autism spectrum disorders (ASD). The cell-adhesion molecule Neuroligin-3 (Nlgn3) has an essential role in the function and maturation of synapses and NLGN3 ASD-associated ...
Andrade, V.M., Avila, M.E., Caracci, M.O., De Ferrari, G.V., Medina, M.A., Opazo, C., Reyes, A.E., Ugarte, G.D., Vargas, M.F., Verdugo, D.A.   +9 more
core   +1 more source

Premise and peril of Wnt signaling activation through GSK-3β inhibition

iScience, 2022
Summary: Wnt signaling pathways have been extensively studied in the context of several diseases, including cancer, coronary artery disease, and age-related disorders.
Samuel M. Law, Jie J. Zheng
doaj  

Targeting the WNT Signaling Pathway in Cancer Therapeutics.

The Oncologist, 2015
The WNT signaling cascade is integral in numerous biological processes including embryonic development, cell cycle regulation, inflammation, and cancer.
D. Tai, K. Wells, J. Arcaroli, Chad Vanderbilt, D. Aisner, W. Messersmith, C. Lieu   +6 more
semanticscholar   +1 more source

Wnt Signaling in Atherosclerosis: Mechanisms to Therapeutic Implications

Biomedicines
Atherosclerosis is a vascular disease in which inflammation plays a pivotal role. Receptor-mediated signaling pathways regulate vascular inflammation and the pathophysiology of atherosclerosis.
Rizwana Afroz, Julie E. Goodwin
doaj   +1 more source