Results 61 to 70 of about 57,140,467 (284)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Sustained knowledge work and thinking time amongst academics: gender and working from home during the COVID-19 pandemic [PDF]

, 2022
The COVID-19 pandemic triggered a migration of workforces to work from home. A key issue for academics was the implications for the ability to carve out ‘thinking time’ to engage in what we term sustained knowledge work, the type of work essential for ...
Bartkiw, T, Lynch, Bernadette, Cooper, R, Peetz, David, Samani, Mojan Naisani, Lynch, B, To, M, Walsworth, Scott, Strachan, G, Troup, C, Ramia, Ioana, de la Harpe, Barbara, To, March, Weststar, Johanna, Strachan, Glenda, Coles, Amanda, Southey, Kim, Campbell, Shelagh, Pyman, Amanda, Pyman, A, Baird, Marian, Coles, A, Banerjee, Rupa, Samani, MN, Peetz, D, Galea, N ; https://orcid.org/, Pike, Kelly, Foster, Jason, Foster, J, Leighton, Catherine, Galea, Natalie, Campbell, S, Charlesworth, Sara, Werth, S, Cooper, Rae, de la Harpe, B, Ressia, S, Baird, M, Walsworth, S, Ressia, Susan, Banerjee, R, Charlesworth, S, Southey, K, Werth, Shalene, Bartkiw, Tim, Troup, Carolyn, Pike, K, Ramia, I ; https://orcid.org/, Weststar, J, Leighton, C   +49 more
core   +1 more source

Work from Home during Pandemic of Covid-19: Effects on Work Life Balance and Job Satisfaction

Journal of Accounting Research, Organization and Economics, 2021
Objective– This study is intended to see the relationship among three variables namely work from home, work life balance, and job satisfaction particularly during COVID-19 pandemic.
Irma Suryani, Megawati Megawati, Sari Rahmani   +2 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Skills for managing work from home scale (SMWFHS) [PDF]

Revista de Administração Pública
This study developed and tested the validity of a scale that measures skills for managing work from home, such as: informing change, searching for information, establishing priorities, setting and adapting goals, assessing work outputs, distributing ...
Lisa Ferreira de Miranda, Lara Barros Martins, Gardênia da Silva Abbad, Juliana Legentil, Luciana Mourão   +4 more
doaj   +1 more source

Sensitive Men and Hardy Women: How Do Millennials, Xennials and Gen X Manage to Work from Home?

Journal of Open Innovation: Technology, Market and Complexity, 2021
Despite the huge number of studies on telework in 2020, the influence of socio-demographic characteristics of workers on their attitudes towards telework continues to raise questions.
Agota Giedrė Raišienė, Violeta Rapuano, Kristina Varkulevičiūtė   +2 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Difficulties in the work-from-home setting, coping mechanisms and work performance among elementary teachers in Subic district

Ho Chi Minh City Open University Journal of Science - Social Sciences
This study involved 228 teachers assigned to public elementary schools in the Division of Zambales, Subic District, Philippines, during the SY 2020 - 2021 and focused on the profile, experiences in the work-from-home setting as encountered by teachers ...
Ivy Casupanan, Jeffrey Reyes
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source