Results 61 to 70 of about 40,829,876 (301)

The future of working from home: a mixed-methods study with IT professionals to learn from enforced working from home

Information Technology & People, 2023
PurposePositive experiences with working from home (WFH) during the Corona pandemic (COVID-19) have motivated many employees to continue WFH after the pandemic. However, factors influencing employees' WFH intentions against the backdrop of experiences during pandemic-induced enforced working from home (EWFH) are heterogeneous.
Simon Lansmann, Jana Mattern, Simone Krebber, Joschka Andreas Hüllmann   +3 more
openaire   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Sustained knowledge work and thinking time amongst academics: gender and working from home during the COVID-19 pandemic

, 2022
The COVID-19 pandemic triggered a migration of workforces to work from home. A key issue for academics was the implications for the ability to carve out ‘thinking time’ to engage in what we term sustained knowledge work, the type of work essential for ...
Bartkiw, T, Lynch, Bernadette, Cooper, R, Peetz, David, Samani, Mojan Naisani, Lynch, B, To, M, Walsworth, Scott, Strachan, G, Troup, C, Ramia, Ioana, de la Harpe, Barbara, To, March, Weststar, Johanna, Strachan, Glenda, Coles, Amanda, Southey, Kim, Campbell, Shelagh, Pyman, Amanda, Pyman, A, Baird, Marian, Coles, A, Banerjee, Rupa, Samani, MN, Peetz, D, Galea, N ; https://orcid.org/, Pike, Kelly, Foster, Jason, Foster, J, Leighton, Catherine, Galea, Natalie, Campbell, S, Charlesworth, Sara, Werth, S, Cooper, Rae, de la Harpe, B, Ressia, S, Baird, M, Walsworth, S, Ressia, Susan, Banerjee, R, Charlesworth, S, Southey, K, Werth, Shalene, Bartkiw, Tim, Troup, Carolyn, Pike, K, Ramia, I ; https://orcid.org/, Weststar, J, Leighton, C   +49 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Decolonizing work: Unpacking the gendered-colonial distinctions between work from home and domestic work

, 2023
Domestic work is nearly always assumed to not ‘directly’ contribute to an economy. The ‘economy’ of a country is in fact produced through the lens of ‘paid vs. unpaid’ work – where only paid work contributes to the GDP.
Dixit, Anukriti, Banday, Muneeb Ul Lateef   +1 more
core  

Organisational support for the work-life balance of home-based workers [PDF]

, 2020
First paragraph: The shift to working from home following the lockdown necessitated by COVID19 has been sudden and significant. Many of the tasks and activities that have traditionally been positioned as ‘impossible’ to conduct online were rapidly and ...
Marks, Abigail, Skountridaki, Lila, Zschomler, Danny, Mallett, Oliver   +3 more
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source