Results 91 to 100 of about 3,063,204 (302)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

CAPACITY FOR WORK AND CARDIOVASCULAR RISK AMONG PREFECTURAL WORKERS ON A UNIVERSITY CAMPUS

Cogitare Enfermagem, 2015
This study aimed to ascertain the relationship of the Work Ability Index with Cardiovascular Risk in workers of the prefecture on a university campus. It is descriptive, exploratory, transversal and quantitative research undertaken in 2012 through the ...
Aline Loiola Moura, Maria do Carmo Lourenço Haddad, José Carlos Dalmas, Vanda Elisa Andres Felli, Paloma de Souza Cavalcante Pissinati   +4 more
doaj   +1 more source

The Third Version of the Copenhagen Psychosocial Questionnaire

Safety and Health at Work, 2019
Introduction: A new third version of the Copenhagen Psychosocial Questionnaire (COPSOQ III) has been developed in response to trends in working life, theoretical concepts, and international experience.
Hermann Burr, Hanne Berthelsen, Salvador Moncada, Matthias Nübling, Emilie Dupret, Yucel Demiral, John Oudyk, Tage S. Kristensen, Clara Llorens, Albert Navarro, Hans-Joachim Lincke, Christine Bocéréan, Ceyda Sahan, Peter Smith, Anne Pohrt   +14 more
doaj   +1 more source

Less-than-Best-Effort capacity sharing over high BDP networks with LEDBAT [PDF]

, 2013
There has been a renewed interest at the Internet Engineering Task Force (IETF) in using Less-than-Best Effort (LBE) methods for background applications.
Kuhn, Nicolas, Lochin, Emmanuel, Mehani, Olivier, Sathiaseelan, Arjuna   +3 more
core  

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Fadiga e capacidade para o trabalho em turnos fixos de doze horas

Revista de Saúde Pública
OBJETIVO: Analisar as variáveis que interferem na percepção de fadiga e na capacidade para o trabalho em trabalhadores que executam suas atividades em turnos fixos diurnos e noturnos.
Ricardo Jorge Metzner, Frida Marina Fischer   +1 more
doaj  

Attitudes towards evaluation of psychiatric disability claims: a survey of Swiss stakeholders

Swiss Medical Weekly, 2015
QUESTIONS: In Switzerland, evaluation of work capacity in individuals with mental disorders has come under criticism. We surveyed stakeholders about their concerns and expectations of the current claim process.
Stefan Schandelmaier, Andrea Leibold, Katrin Fischer, Ralph Mager, Ulrike Hoffmann-Richter, Monica Susanne Bachmann, Sarah Kedzia, Jason Walter Busse, Gordon Henry Guyatt, Joerg Jeger, Renato Marelli, Wout Ernst Lodewijk De Boer, Regina Kunz   +12 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Assessing the Effectiveness of Assistance in Capacity Development [PDF]

, 2009
{Excerpt} Feedback is a circular causal process whereby some portion of a system’s output is returned to the input to control the dynamic behavior of the system. In organizations, feedback is the process of sharing observations, concerns, and suggestions
Serrat, Olivier
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source