Results 81 to 90 of about 20,133,839 (301)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Evaluation of musculoskeletal symptoms and of work ability in a higher education institution

Fisioterapia em Movimento
Introduction Work-related musculoskeletal disorders (WMSDs) represent a significant object of study for the field of occupational health, as they can lead to absenteeism, compensation costs and different levels of functional disability.
Denise Hollanda Iunes, Melissa Louyse Duarte, Leticia do Vale Pereira, Murilo César do Nascimento, Valdeci Carlos Dionisio   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Functional capacity evaluations in medico-legal contexts: a scoping review of best practices, limitations, and areas for improvement

Frontiers in Rehabilitation Sciences
IntroductionFunctional Capacity Evaluations (FCEs) are commonly used to assess individuals' capacities in relation to work demands, with growing application in medico-legal contexts.
Lisa Schwab, Dominique Van de Velde, Lutgart Braeckman, Stijn De Baets, Stijn De Baets   +4 more
doaj   +1 more source

The impact of work-related psychosocial factors on the health and work ability of municipal transit agents

Revista Brasileira em Promoção da Saúde, 2016
Objective: To analyze the impact of work-related psychosocial factors on the health and work ability of municipal transit agents. Methods: A cross-sectional study was carried out with a sample of 118 subjects at the municipality of Rio de Janeiro, Rio de
Aldo Pacheco Ferreira, Ana Paula Carneiro Carvalho   +1 more
doaj   +1 more source

Evaluation of Regional Humanitarian Work in West Africa [PDF]

, 2007
West Africa is fraught by conflict and natural disaster in a context of chronic poverty and human deprivation, which disproportionately affects women. The regional humanitarian project aims to enhance OGB and partners capacities to identify and respond ...
Mubayiwa, Raymond S
core  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Testando o Modelo da Casa da Capacidade para o Trabalho entre profissionais do setor hospitalar

Revista Brasileira de Epidemiologia
RESUMO: Objetivo: Testar o Modelo da Casa da Capacidade para o Trabalho, verificando a hierarquia das dimensões propostas para um grupo de trabalhadores do setor hospitalar.
Maria Carmen Martinez, Maria do Rosário Dias de Oliveira Latorre, Frida Marina Fischer   +2 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source