Results 61 to 70 of about 20,133,839 (301)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Medicina y Seguridad del Trabajo, 2011 Introducción: Los países industrializados están sufriendo importantes transformaciones en su evolución demográfica, caracterizado por el envejecimiento de la población (disminución de la tasa de natalidad, incremento de la población adulta y aumento de ...
Beatriz de León Luis, Schyrley Díaz
doaj
Evaluation of Working Capacity in Case of Mental Disorders
Medical Archives, 2011 Incidence of mental disorders in our country and in the world is growing and significantly impact working capacity. The goal of the study: to investigate which group of mental disorders and to what extent impacts the disability comparing two analyzed years (1999 and 2009).420 subjects were processed (143 in 1999 and 277 in 2009) from the Una-Sana ...
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Neural Regeneration Research, 2015 Previous diffusion tensor imaging (DTI) studies regarding pediatric patients with motor dysfunction have confirmed the correlation between DTI parameters of the injured corticospinal tract and the severity of motor dysfunction.
Jin Hyun Kim, Yong Min Kwon, Su Min Son
doaj +1 more source
, 2007 French version available in IDRC Digital Library: Renforcement concerté des capacités : phase 3 de l'évaluation stratégique des activités de renforcement des capacités du CRDI; élaboration du cadre d'évaluationThis “Evaluation Highlights ...
IDRC. Evaluation Unit
core
Evaluation Workshops for Capacity Building in Welfare Work : Some Swedish Examples
, 2008 Ever increasing demands are being made on welfare organizations to display efficiency. Evaluation workshops constitute a form of learning for the purposes of building up competence to conduct evaluations within welfare organizations, with the support of ...
Karlsson, Per-Åke, +3 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Interview guide used across 5 test facilities in 3 African countries to explore enablers, barriers and effects of a research capacity strengthening programme, targeting development of a Quality Management System compliant with Good Laboratory Practice ...
Capacity Research, Centre for
core +1 more source