Results 91 to 100 of about 14,513,002 (301)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hubungan antara Resiliensi dengan Work Engagement pada Guru SLB

Psikoislamika, 2014
Penelitian ini bertujuan untuk mengetahui tingkat work engagement dan resiliensi pada guru di sekolah luar biasa (SLB), serta hubungan antara resiliensi dengan work engagement pada guru di SLB Putra Jaya. Penelitian ini menggunakan pendekatan kuantitatif
Eka Yulia Asfiyah, Endah Kurniawati P
doaj   +1 more source

The Dirty Workers Among Us: The Intervening Role of Job Crafting and the Moderating Role of Leader Member Exchange in The Evaluation of Self Determination & Work Engagement

, 2022
This study evaluates job crafting as a strategy the hospital may utilize with guest services personnel to reduce turnover, increase work engagement, and improve the quality of patient care.
Davis, DeAndrea Y.
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Navigating fragmented services: a gender-based violence (GBV) critical feminist analysis of women’s experiences engaging with health and social supports in three Canadian cities

BMC Public Health
Background Gender-based violence (GBV) remains a pervasive public health crisis with devastating impacts on women’s health and well-being. Women experiencing GBV face considerable barriers accessing appropriate and timely health and social services. This
Katherine Rudzinski, Lara F. Hudspith, Adrian Guta, Scott Comber, Linda Dewar, Wendy Leiper, Kim Hawkins, Lady Laforet, Rajwant Raji Mangat, Phoebe M. Long, Ingrid Handlovsky, Vicky Bungay   +11 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Counterbalancing work-related stress? Work engagement among intensive care professionals [PDF]

, 2018
Working in an Intensive Care Unit (ICU) is increasingly complex and is also physically, cognitively and emotionally demanding. Although the negative emotions of work-related stress have been well studied, the opposite perspective of work engagement might
Schaufeli, WB, van Mol, Margo, Nijkamp, Marjan D.; id_orcid, Work and Organizational Psychology: Occupational Health Psychology, Margo M.C. van Mol, Kompanje, Erwin J. O., Erwin J.O. Kompanje, Kompanje, Erwin, Bakker, Jan, Nijkamp, Marjan D., Nijkamp, MD, Jan Bakker, Bakker, Jan; id_orcid, Schaufeli, Wilmar B., van Mol, Margo M.C., Kompanje, Erwin J.O., Bakker, Hanneke, Van Mol, Margo M. C., Marjan D. Nijkamp, Wilmar B. Schaufeli   +19 more
core   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Scripting deliberative policy-making:Dramaturgic policy analysis and engagement know-how [PDF]

, 2015
Public engagers are officials tasked with facilitating collaborative performances in the theatres of deliberation that increasingly populate local governance.
Escobar, Oliver; id_orcid
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source