Results 81 to 90 of about 14,962,284 (302)
BMC PsychiatryBackground Untreated mental illness poses a significant threat to achieving global mental health targets. The increasing incidence of common mental disorders in India exacerbates the treatment gap.
Saju Madavanakadu Devassy +7 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Passion for Work: Work Engagement versus Workaholism [PDF]
, 2010 Introduction: Nothing great in the world has been accomplished without passion. Georg Wilhelm Friedrich Hegel (1770-1831) Is passion needed for excellent performance? The question of what predicts outstanding performance at work remains timely and relevant. The term “passion for work” emerged from qualitative research on entrepreneurs’ motivation, and
Gorgievski, Marjan, Bakker, Arnold
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Job performance explains work engagement
Annals of Business Administrative Science, 2018 This study analyzes the relationship between work engagement (WE) and job performance based on data from 3,296 individuals obtained in an internet survey.
Nobuyuki Inamizu, Mitsuru Makishima
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Job autonomy in relation to work engagement and workaholism : mediation of autonomous and controlled work motivation [PDF]
, 2018 Objectives: This study integrates the Self Determination Theory and the Job Demands - Resource model in explaining motivational antecedents of 2 forms of excessive work: work engagement and workaholism.
Tokarz, Aleksandra +5 more
core +2 more sources
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Work environments, creative behaviours, and employee engagement [PDF]
, 2016 While research regarding the work environments of successful organisations reports separate outcomes of creative behaviours and highly engaged employees, little research has been carried out to simultaneously investigate both notions.
Stanley, Tracy
core
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source