Results 61 to 70 of about 1,229,730 (302)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Covid geographies of home and work: privileged (im)mobilities? [PDF]

, 2023
For hundreds of millions of people globally, the covid-19 pandemic has fundamentally re-ordered the relationship between where one resides and where one’s paid work is done. Much ink has justifiably been spilled on the nature, drivers and consequences of
David McCollum, McCollum, David
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Work from Home during Pandemic of Covid-19: Effects on Work Life Balance and Job Satisfaction

Journal of Accounting Research, Organization and Economics, 2021
Objective– This study is intended to see the relationship among three variables namely work from home, work life balance, and job satisfaction particularly during COVID-19 pandemic.
Irma Suryani, Megawati Megawati, Sari Rahmani   +2 more
doaj   +1 more source

On working from home in European countries

International Journal of Manpower, 2023
PurposeThe authors analyzed the evolution of working from home (WFH) within industries in 12 European countries in the period 2008–2017 and studied its relationship with information and communication technologies (ICT).Design/methodology/approachThe authors used data from the European Union Labour Force Survey (EU-LFS) to document the trends and levels
Jerbashian, Vahagn, Vilalta-Bufí, Montserrat   +1 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Effectiveness of Employee Performance of Ministry of Religious Affairs during Work from Home and The Factors that Influence It

Jurnal Manajemen, 2022
Working from home as a new method of flexible work is being accelerated due to the Corona Virus Disease 2019 (COVID-19) pandemic. This new work system resulted in several changes that occurred in the workplace related to the work environment. Furthermore,
Siti Rosidah, M. Syamsul Maarif, Anggraini Sukmawati   +2 more
doaj   +1 more source

The future of working from home: a mixed-methods study with IT professionals to learn from enforced working from home

Information Technology & People, 2023
PurposePositive experiences with working from home (WFH) during the Corona pandemic (COVID-19) have motivated many employees to continue WFH after the pandemic. However, factors influencing employees' WFH intentions against the backdrop of experiences during pandemic-induced enforced working from home (EWFH) are heterogeneous.
Simon Lansmann, Jana Mattern, Simone Krebber, Joschka Andreas Hüllmann   +3 more
openaire   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Skills for managing work from home scale (SMWFHS) [PDF]

Revista de Administração Pública
This study developed and tested the validity of a scale that measures skills for managing work from home, such as: informing change, searching for information, establishing priorities, setting and adapting goals, assessing work outputs, distributing ...
Lisa Ferreira de Miranda, Lara Barros Martins, Gardênia da Silva Abbad, Juliana Legentil, Luciana Mourão   +4 more
doaj   +1 more source