Results 121 to 130 of about 242,010 (302)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Effect of the Single-Point Incremental Sheet Forming Process Parameters on the Mechanical Properties of Zinc Alloy Drawpieces

open access: yesAdvances in Mechanical and Materials Engineering
Single-point incremental forming (SPIF) is a method of forming sheet metal components in a variety of industries. SPIF involves the gradual deformation of the sheet metal using a pin tool.
Łukasz Kuczek   +3 more
doaj   +1 more source

A Data-Driven Approach for Studying the Influence of Carbides on Work Hardening of Steel. [PDF]

open access: yesMaterials (Basel), 2022
Vittorietti M   +4 more
europepmc   +1 more source

Plastic instability in complex strain paths predicted by advanced constitutive equations [PDF]

open access: yes
The present paper aims at predicting plastic instabilities under complex loading histories using an advanced sheet metal forming limit model. The onset of localized necking is computed using the Marciniak-Kuczinslcy (MK) analysis [I] with a physically ...
Barlat, F   +3 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

The complex binder based on Portland cement andash-and-slag wastes from thermal power stations [PDF]

open access: yes, 2019
Increase in the balance of boiler and furnace fuel of the energy sector of the Republic of Belarus the proportion of own energy resources (milling peat and wood chips) places priority on resolving the issues of utilization of ash-and-slag wastes and ...
Vysotskaya, Maryia
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

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