Results 71 to 80 of about 2,628,875 (314)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Analysis of the Mediating Role of Self-Efficacy and Self-Esteem on the Effect of Workload on Burnout’s Influence on Nurses’ Plans to Work Longer

open access: yesFrontiers in Psychology, 2018
At the present time, we know that there is a positive relationship between self-efficacy and self-esteem in which positive beliefs about one’s own efficacy increase one’s sense of self-worth as stressful situations of a heavy workload are coped with ...
María del Mar Molero   +3 more
doaj   +1 more source

Self-identity, embodiment and the development of emotional resilience [PDF]

open access: yes, 2013
This article is made available through the Brunel Open Access Publishing Fund. Copyright @ The Author 2013. Published by Oxford University Press on behalf of The British Association of Social Workers.
Rajan-Rankin, S, Sweta Rajan-rankin
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Boundless and bounded interactions in the knowledge work process : the role of groupware technologies. [PDF]

open access: yes, 2000
This paper considers how the time/space distanciation that the introduction of a groupware technology provided was implicated in the knowledge work process.
Hayes, Niall, Hayes, N
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Does Self-Efficacy Moderate the Effect of Customer Incivility on Work Engagement?

open access: yesInternational Research Journal of Business Studies
This research aims to determine how customer incivility can impact frontlines’ work engagement and how self-efficacy moderates the relationship between customer incivility and frontlines’ work engagement. This research uses a saturated or census sampling
I Made Siddhi Wisesa   +1 more
doaj   +1 more source

INDIGENOUS PRACTICE: SOME INFORMED GUESSES –SELF-EVIDENT BUT IMPOSSIBLE

open access: yes, 2003
Ever since Western social work was exported to Africa an ongoing debate has been taking place on whether it fits the African context. Most of this debate, however, has revolved around Western social work’s techniques rather than on its ends, which, being
Bar-On, Arnon
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

The Impact of Work-Famıly Enrıchment on Work Engagement: Examınıng the Medıatıng Roles of Job Satısfactıon and Self-Effıcacy

open access: yesAPMBA (Asia Pacific Management and Business Application)
This research examines the effect of work-family enrichment on work engagement through self-efficacy and job satisfaction as mediating variables among women entrepreneurs in Bali.
Ni Made Dwi Puspitawati   +3 more
doaj   +1 more source

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