Results 71 to 80 of about 9,616,910 (301)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Assessment of the noise annoyance among subway train conductors in Tehran, Iran
Noise and Health, 2014 Subway transportation system is a new phenomenon in Iran. Noise annoyance interferes with the individual′s task performance, and the required alertness in the driving of subway trains.
Mansoureh Hamidi +4 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
High Performance Work Systems [PDF]
Research, summarized and classified in the work of Delery and Doty (1996), Guest (1997), Paauwe and Richardson (1997) and Boselie et al. (2001), suggests significant impact of Human Resources Management (HRM) on the competitive advantage of organizations.
Boselie, J.P.E.F., Wiele, A. van der
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
بهداشت کار و ارتقای سلامت, 2021 Introduction: Workers' health status is one of the main factors affecting industry productivity. Therefore, effective employee periodic examinations are important not only for the benefit of industries and for improving the health of workers but also for
Abbas BAHRAMI +3 more
doaj
Jema: Jurnal Ilmiah Bidang Akuntansi dan Manajemen, 2020 Islam is a comprehensive religion that covers not only the ritual worship aspect but also ethics and acts of business. The field of Islamic work ethics has been studied by many researchers in different study settings.
Miswanto Miswanto +2 more
doaj +1 more source
RPPM : Rapid Performance Prediction of Multithreaded workloads on multicore processors [PDF]
, 2019 Analytical performance modeling is a useful complement to detailed cycle-level simulation to quickly explore the design space in an early design stage. Mechanistic analytical modeling is particularly interesting as it provides deep insight and does not ...
Akram, Shoaib +3 more
core +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Advances in Public HealthConsumption of fast-food in adolescence is detrimental to mental and physical health. However, data on the temporal trends of fast-food consumption in this population are scarce, particularly from non-Western or non-high-income settings.
Lee Smith +10 more
doaj +1 more source