Results 31 to 40 of about 232,611 (270)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Interview study exploring how global health partnership principles are enacted and recommendations for practice

BMJ Open
Background Effective global health partnerships can strengthen and improve health and healthcare systems across the world; however, establishing and maintaining effective partnerships can be challenging.
Lucie Byrne-Davis, Natalie Carr, Jo Hart, Rebecca Rose Turner, Eleanor Bull, Jessica Fraser   +5 more
doaj   +1 more source

Are the Global Strategic Directions for Strengthening Nursing and Midwifery 2016–2020 being implemented in countries? Findings from a cross-sectional analysis

Human Resources for Health, 2019
Background Nurses and midwives are the largest component of the health workforce in many countries. The World Health Organization (WHO) together with its partners facilitates the joint development of strategic policy guidance for countries to support the
Onyema Ajuebor, Carey McCarthy, Yin Li, Sumaya Mohamed Al-Blooshi, Nonhlanhla Makhanya, Giorgio Cometto   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

How do gender dynamics influence the preferences and decisions of an individual in selecting a technical and vocational education and training (TVET) program in Bhutan?

Journal of Innovation in Polytechnic Education
This research explores various factors that influence the preferences and decisions of women when selecting specific Technical and Vocational Education and Training (TVET) programs, focusing on individual interests, career prospects and employment ...
Tenzin Choden, Pemma Lhaden Lhendup, Sangay Dorji   +2 more
doaj   +1 more source

Retaining the perinatal care workforce: Lessons learned from experienced physicians who no longer attend deliveries [PDF]

, 2023
Tyler Barreto, Melina Taylor, Jessica Taylor Goldstein, Aimee R. Eden   +3 more
openalex   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

An examination of Child and Adolescent Mental Health Services for Māori rangatahi [youth]

International Journal of Adolescence and Youth, 2016
This article offers a review of the literature illustrating factors that can contribute to responsive Child and Adolescent Mental Health Services (CAMHS) for Māori (indigenous population of Aotearoa/New Zealand) rangatahi [12–19-year-old youths].
Kahu McClintock, Roimata Tauroa, Graham Mellsop   +2 more
doaj   +1 more source