Results 101 to 110 of about 52,576 (263)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Managers in the context of small business growth: a qualitative study of working conditions and wellbeing

BMC Public Health
Purpose In view of the importance of managers’ wellbeing for their leadership behaviour, employee health, and business effectiveness and survival, a better understanding of managers’ wellbeing and working conditions is important for creating healthy and ...
Elena Ahmadi, Daniel Lundqvist, Gunnar Bergström, Gloria Macassa   +3 more
doaj   +1 more source

Mental wellbeing of children engaged in agricultural work activities and quality of family environment.

Annals of agricultural and environmental medicine : AAEM, 2007
A considerable percentage of Polish children from agricultural families are engaged by their parents in performing work activities on farms. The performance of these tasks arouses various emotional reactions in children, from the feeling of threat, fear and anxiety, to the feeling of satisfaction, being contented and proud.
Stanisław Lachowski, Lachowska, Bogusława   +1 more
openaire   +1 more source

The Role of Strategically Designed Work Environments for the Wellbeing and Performance of Generation Z Employees

Journal of Intelligent Decision Making and Granular Computing
Office workers spend a substantial proportion of their time within workplace environments, underscoring the importance of workplace design in shaping employee outcomes. This study examines the extent to which workplace design features influence the wellbeing and productivity of Generation Z employees. Data were collected through an online questionnaire
Yan Chen, Junpeng Lyu, Michael Pitt
openaire   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Work Environment and Occupational Wellbeing among Employees: The Intervening Role of Workplace Ostracism

Journal for Social Science Archives
This study examined the relationships between organizational culture, workplace ostracism, and occupational well-being among employees. It was hypothesized that workplace ostracism mediates the relationship between organizational culture and occupational well-being.
null Muhammad Faran, null Eemaan Zainab, null Awais Aslam Malik, null Afreen Komal   +3 more
openaire   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

Sonographer wellbeing in Australia: Perceptions of job demands and resources in clinical working environments

Sonography
AbstractIntroductionThe concept that job characteristics can have a profound impact on employee wellbeing has been well documented. This manuscript aims to highlight the job demands and resources experienced by Australian sonographers, and those resources perceived to be the most effective at improving workplace wellbeing.MethodsUtilising the Job ...
Catherine Hall, Silvia Pignata, Mark Tie, Eva Bezak, Jessie Childs   +4 more
openaire   +1 more source