Results 61 to 70 of about 52,576 (263)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Remote Work and the Psychosocial Work Environment: The Role of Contact

Nordic Journal of Working Life Studies
Remote work is fundamentally changing the organization of work, replacing the physical work environment of the office and creating a spatial distance between colleagues.
Mari Holm Ingelsrud, Vilde Hoff Bernstrøm, Wendy Nilsen   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Working from home environments to enhance wellbeing and productivity

This presentation examines the essential qualities of effective home working en- vironments and their impact on well-being and productivity.
Abuzeinab, Amal, Dye, Abigail, Ogunbode, Charles, Ghaziani, Rokhshid   +3 more
openaire   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Attending Weak Signals: The Prevention of Work-related Illnesses

Nordic Journal of Working Life Studies, 2017
This article examines the characteristics of communication among managers, human resource (HR) experts, and occupational health care specialists, as they deal with such informal information as weak signals in the prevention of work-related illnesses ...
Roy Liff, Ann-Charlotte Eriksson, Ewa Wikström   +2 more
doaj   +1 more source

PSYCHOSOCIAL WORK ENVIRONMENT AND EMPLOYEE WELLBEING: STRESS AND PERSONALITY EFFECTS

Veredas do Direito
The study examines the impact of the psychosocial work environment, measured as a high-order construct, on employee wellbeing, with stress as a mediator and personality as a moderator.  The study collects the data from 230 employees across multiple sectors in Pakistan.
Waqar Akbar, Manoj Kumar, Muhammad Asad Ali, Muhammad Mubeen, Zawiah Mat   +4 more
openaire   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Organizational Support and Work Engagement: Onsite, Hybrid, and Remote Work during COVID-19

Nordic Journal of Working Life Studies
We analyzed the association of job autonomy, mental demands, and organizational support on work engagement and the moderating role of organizational support between mental demands and work engagement.
Kirsikka Selander, Tuomo Alasoini
doaj   +1 more source