Results 151 to 160 of about 10,962,408 (345)

Serial Shock Severity Assessment Within 72 Hours After Diagnosis: A Cardiogenic Shock Working Group Report.

Journal of the American College of Cardiology
BACKGROUND The Cardiogenic Shock Working Group-modified Society for Cardiovascular Angiography and Interventions (CSWG-SCAI) staging was developed to risk stratify cardiogenic shock (CS) severity.
V. Ton, Song Li, K. John, Bo-Rui Li, E. Zweck, M. Kanwar, S. Sinha, J. Hernández-Montfort, A. Garan, R. Goodman, A. Faugno, M. Farr, S. Hall, R. Kataria, M. Guglin, E. Vorovich, M. Pahuja, S. Vallabhajosyula, S. Nathan, Jacob Abraham, N. Harwani, Gavin W. Hickey, Andrew D. Schwartzman, W. Khalife, C. Mahr, Ju Kim, A. Bhimaraj, P. Sangal, Q. Kong, K. Walec, P. Zazzali, Justin Fried, D. Burkhoff, Navin K. Kapur   +33 more
semanticscholar   +1 more source

Injuries associated with long working hours among employees in the US mining industry: risk factors and adverse outcomes

Occupational and Environmental Medicine, 2019
Objectives The mining industry is increasingly adopting extended workdays of 10–12 hour shifts. Studies demonstrate that long work hours are associated with psychomotor impairments caused by fatigue and an increased risk of injury.
L. Friedman, K. Almberg, R. Cohen
semanticscholar   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Human Right for Fair Wage: sociological aspect

Vestnik Omskoj Ûridičeskoj Akademii, 2012
The article summarizes the results of sociological research devoted to the analysis of the fair wage problem. The authors analyze the dynamics of labor load and the level of wages in the economic market conditions taking as an example the Omsk ...
Ponomareva T. M., Kalyuga E. A.
doaj  

Radiografía de la formación médico interno residente (MIR): estudio descriptivo sobre las condiciones laborales y formativas en la provincia de Valencia

Educación Médica
Resumen: Introducción: las condiciones laborales de los médicos internos residentes (MIR) han demostrado tener un gran impacto en su salud y formación. Durante los últimos años se han publicado los primeros estudios analizando esta realidad. Sin embargo,
Lucía Escabias Criado, Lucía De La Puente, Paula Sala Ivars, Pablo Estrella-Porter, Juan Pablo Carrasco   +4 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Decent working time: New trends, new issues. [PDF]

Includes selected papers from the 9th International Symposium on Working Time, Paris (2004), looking at the increasing use of results-based employment relationships for managers and professionals, and the increasing fragmentation of time to more closely ...
Michon, François, Lallement, Michel, Boulin, Jean-Yves, Messenger, Jon C.   +3 more
core  

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source