Results 41 to 50 of about 3,276,396 (351)

The Effect of Employed Women’s Working Hours on Fertility [PDF]

open access: yesجامعه شناسی کاربردی, 2018
Introduction Women’s working hours is known as an important factor on childbearing. The question this paper tries to address is “whether the available part-time working schedule in Isfahan has any impact on fertility to better understand women’s behavior
Mehri Shams
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

STRESSORS IN NURSING WITH DOUBLE OR MORE WORKING HOURS

open access: yesRevista de Pesquisa Cuidado é Fundamental Online, 2013
Resumo Objetivo: investigar os principais agentes estressores nos trabalhadores de enfermagem com dupla ou mais jornada de trabalho; verificar os principais sinais e sintomas indicadores de estresse.
Marlinir Bezerra de Lima   +4 more
doaj   +5 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Duration of working hours: health and socio-economic Implications

open access: yesRevista Chilena de Terapia Ocupacional, 2015
A topic of relevance for occupational therapy from their bases, has been how the person distributes the time of their activities and through this reach “Occupational Balance”, recognizing its importance to the health of the human.
Christian Moretti A.
doaj   +1 more source

Residents' hours of work

open access: yesBMJ, 2002
To many, “resident physician” conjures up an image of long hours of work, fuelled by caffeine and adrenaline. This overlooks the reality that residency is an educational experience that completes a physician's preparation for independent practice. About 100 000 resident doctors in the United States—as providers of care and as learners—will be affected ...
Ingrid, Philibert, Paul, Barach
openaire   +3 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

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