Results 101 to 110 of about 32,894 (307)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Identification оf World Class Universities

open access: yesМир новой экономики, 2018
The article discusses the concept of world-class universities and the author’s understanding of the term, allowing not only to identify these objects but also to quantify their international potential.
E. V. Balatsky, N. A. Ekimova
doaj  

QS criteria as a basis for evaluation of the Institute of Civil Engineering of the Saint-Petersburg State Polytechnical University [PDF]

open access: yesСтроительство уникальных зданий и сооружений, 2014
St.Petersburg State Polytechnical University was founded in 1899. Recently SPbSPU became "National Research University", also known in Russia and abroad as Polytechnic Institute - a recognized Russian and world-wide leader in the field of higher ...
Olga Sergeevna Gamayunova   +3 more
doaj  

Salience in Quality Disclosure: Evidence from the U.S. News College Rankings [PDF]

open access: yes
How do rankings affect demand? This paper investigates the impact of college rankings, and the visibility of those rankings, on students' application decisions. Using natural experiments from U.S.
Jonathan Smith, Michael Luca
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

UMPSA excels at 153rd best in Asia in QS World University Rankings: Asia 2026 [PDF]

open access: yes
PEKAN, 4 November 2025 – Universiti Malaysia Pahang Al-Sultan Abdullah (UMPSA) continues to demonstrate its excellence in higher education, ranking among the top 200 universities in Asia, placing 153rd overall and 41st in Southeast Asia, according to the
Safriza, Baharuddin
core  

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

Taking rankings seriously [PDF]

open access: yes, 2018
The Centre has celebrated the fact that India has jumped 30 points ahead in the World Bank’s Ease of Doing Business Rankings 2018. Yet, India will not be able to create the necessary ecosystem to promote a viable environment that will help us achieve ...
Raj Kumar, C.
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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