Evaluation of Analgesic Tolerance Induced by Metamizole in the Writhing Test Model [PDF]
Ciencia Latina Revista Científica Multidisciplinar, 2023 Analgesic tolerance is defined as the need for increasing doses to achieve the intended effect. In this paper we present experimental data from the search for analgesic tolerance induced by metamizole in a pain model induced by 0.9% acetic acid known as abdominal constriction test or Writhing test.
Elda A. Garcia Mayorga +4 more
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The synergistic interaction between rilmenidine and paracetamol in the writhing test in mice
Naunyn-Schmiedeberg's Archives of Pharmacology, 2009 The aim of the study was to ascertain antinociceptive effects of rilmenidine, a second-generation imidazoline-alpha-2-adrenoreceptor agonist, and to see whether rilmenidine was able to increase the analgesic effects of paracetamol in the writhing test in mice.
Soukupova M, Dolezal, T., Krsiak, M.
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Horizonte Médico, 2018 Objective: To evaluate the dose-response analgesic effect of metformin in an acute pain event in rodents. Materials and methods: Eighty (80) mice were used. The analgesic effect was evaluated using the abdominal writhing test in mice. Eight (8) groups of 10 mice each were formed: one diclofenac 8 mg/kg group, one tramadol group, one target group, and ...
Lujan-Carpio, E. +2 more
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Analgesic activity test of Inggu leaf (Ruta angustifolia [L.] Pers) with Tail Flick and Writhing Test method [PDF]
Journal of Natural Sciences and Mathematics ResearchPain is a sensory and emotional experience related to tissue damage. This study aims to determine the analgesic effect of ethanol extract from Inggu leaves and the effective dose of ethanol extract of Inggu leaves by tail flick and writhing test methods.
Mia Ariasti, Lalu Busyairi Muhsin
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1,2-propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia. [PDF]
Animal Model Exp MedThis study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Li X, Chen Y, Xiao X, Xu G.
europepmc +2 more sources
Acetic acid induced painful endogenous infliction in writhing test on mice. [PDF]
J Pharmacol Pharmacother, 2012 Gawade SP.
europepmc +4 more sources
Sex Differences in the Effects of L-Menthol on Nociception in the Hot Plate Test and Acetic Acid Writhing Test in BALB/c Mice. [PDF]
Iran J Med SciSex differences can influence the effects of opioid and non-opioid analgesics. This study evaluated the antinociceptive effects of L-menthol in male and female mice.This experimental study was conducted in 2024 at Shiraz University of Medical Sciences (Shiraz, Iran). Forty-two BALB/c mice (21 males, 21 females) were randomLy allocated into three groups
Ahmadnasr M +4 more
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Phytochemical Profiling and Safety Assessment of Maerua crassifolia Forssk. Aerial Parts Infusion With Pharmacological Validation of Its Analgesic and Anti-Inflammatory Activities. [PDF]
ChemistryOpenRich in phenolic compounds, Maerua crassifolia Forssk. aerial parts infusion combines strong antioxidant capacity with a favorable acute safety profile. It produces dose‐dependent analgesic and anti‐inflammatory effects in vivo, approaching reference‐drug activity.
Benazzi L +6 more
europepmc +2 more sources
Efek Analgesik Ekstrak Etanol Zingiber cassumunar Roxb. pada Mencit dengan Metode Writhing Test
Jurnal Medik Veteriner, 2020 Penelitian bertujuan untuk menguji efek analgesik ekstrak etanol Zingiber cassumunar Roxb. pada mencit yang diinduksi dengan asam asetat. Penelitian ini merupakan penelitian eksperiment posttest only control design, menggunakan metode writhing test ...
Qonita Bajuber +2 more
doaj +1 more source
In-Vivo Analgesic And Anti-Inflammatory Effects Of Eel (Anguilla bicolor bicolor) Oil [PDF]
Pharmaciana, 2019 Analgesic and anti-inflammatory tests of eel (Anguilla bicolor bicolor) oil on animal models have been performed. Previous studies have proven that oral administration of EPA and DHA exhibits analgesic and anti-inflammatory effects.
Heru Sasongko +3 more
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