Results 91 to 100 of about 3,652,190 (341)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Writing the Self, Drawing the Self: Identity and Self-Reflexivity in Craig Thompson’s Graphic Memoir Blankets

Cultura, Lenguaje y Representación, 2015
The aim of this article is to identify some of the key conventions and narrative patterns that graphic memoirists may use in order to articulate their own sense of identity, and deal with issues of truth, ethics, and representation through visual and ...
Mercedes Peñalba García
doaj  

Applying the ‘Social Turn’ in writing scholarship to perspectives on writing self-efficacy

Journal of Learning Development in Higher Education, 2019
The aim of this paper is to explore the fit between the cognitive concept of writing self-efficacy and a socially constructed epistemology of writing.
Kim M. Mitchell, Diana E. McMillan, Michelle M. Lobchuk   +2 more
doaj   +1 more source

Self-reported problems of L1 and L2 college writers: what can writing instructors do? [PDF]

, 2011
Understanding self-reported problems of L1 and L2 writers regarding the writing process holds important pedagogical implications for instructors to address their students’ specific writing needs.
Bekar, Mira
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The Relationship between Writing Skills, Writing Self-Efficiacy, and Writing Motivation of Gifted Students Enrolled in Science and Art Centers (SACs)

e-Kafkas Eğitim Araştırmaları Dergisi
The aim of this study is to examine the relationship between the writing skills of gifted secondary school students and their writing self-efficacy and motivation. This quantitative research was designed according to the correlational survey method.
Abdülkadir Bektaş, Ergün Yurtbakan
doaj   +1 more source

Autonomous Boat Control Software Design Using Model-Based Systems Engineering [PDF]

, 2019
While there is considerable buzz about self-driving cars, self-driving boats are actually more fully developed. The Boat Hardware Control Platform Team was tasked with developing a fleet of small autonomous boats that travel to a destination while ...
Nelson, Noah
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Investigating Writing Self-Efficacy and Writing Self-Regulated Learning Strategies Across Different Writing Proficiency Levels in Chinese English Majors: A Mixed-Methods Design

SAGE Open
Writing self-efficacy and writing self-regulated learning (SRL) strategies are pivotal factors influencing writing proficiency from a social cognitive perspective.
Peiqi Zhu, Xiaohui Sun
doaj   +1 more source