Results 171 to 180 of about 5,535 (193)

Comparison of the proteomic landscape in experimental ischemia reperfusion with versus without ischemic preconditioning. [PDF]

Sci Rep
Kakaei Y, Hussain S, Elmahdy A, Berger E, Shekka Espinosa A, Sevastianova V, Sheybani Z, Al-Awar A, Kalani M, Jha S, Zulfaj E, Nejat A, Jha A, Pylova T, Krasnikova M, Andersson EA, Silva VRR, Omerovic E, Redfors B.   +18 more
europepmc   +1 more source

WW domain-containing oxidoreductase’s role in myriad cancers: Clinical significance and future implications

Experimental Biology and Medicine, 2014
The WW domain-containing oxidoreductase (WWOX) gene, encodes a tumor suppressor located on 16q23.1, spanning FRA16D, one of the most active common fragile sites in the human genome, that is altered in numerous types of cancer. WWOX’s alteration in these myriad cancers is due to disparate mechanisms including loss of heterozygosity, homozygous deletion ...
Rami Aqeilan
exaly   +3 more sources

WWOX (WW domain containing oxidoreductase) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2008
Review on WWOX (WW domain containing oxidoreductase), with data on DNA, on the protein encoded, and where the gene is implicated.
Frances Kay Huebner
exaly   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

Expression of WW domain-containing oxidoreductase WOX1 in the developing murine nervous system

Neuroscience, 2004
WW domain-containing oxidoreductase WOX1, also known as WWOX or FOR, is a proapoptotic protein and a putative tumor suppressor. Hyaluronidases such as PH-20, Hyal-1 and Hyal-2 induce the expression of WOX1, and hyaluronidases and hyaluronan are involved in the embryonic development.
Ming-Shiun Tsai
exaly   +3 more sources

WW domain-containing oxidoreductase: a candidate tumor suppressor

Trends in Molecular Medicine, 2007
Common fragile site gene WWOX encodes a candidate tumor suppressor WW domain-containing oxidoreductase. Alteration of this gene, along with dramatic downregulation of WWOX protein, is shown in the majority of invasive cancer cells. Ectopic WWOX exhibits proapoptotic and tumor inhibitory functions in vitro and in vivo, probably interacting with growth ...
Nan-Shan, Chang, Li-Jin, Hsu, Yee-Shin, Lin, Feng-Jie, Lai, Hamm-Ming, Sheu   +4 more
openaire   +2 more sources

Hyaluronidase Induction of a WW Domain-containing Oxidoreductase That Enhances Tumor Necrosis Factor Cytotoxicity [PDF]

Journal of Biological Chemistry, 2001
To determine how hyaluronidase increases certain cancer cell sensitivity to tumor necrosis factor (TNF) cytotoxicity, we report here the isolation and characterization of a hyaluronidase-induced murine WW domain-containing oxidoreductase (WOX1). WOX1 is composed of two N-terminal WW domains, a nuclear localization sequence, and a C-terminal alcohol ...
Nan-Shan Chang, John Heath
exaly   +3 more sources

Expression of WW domain‐containing oxidoreductase and its clinical implication in endometrial adenocarcinoma patients with metabolic syndrome

Asia-Pacific Journal of Clinical Oncology, 2021
AbstractAimMetabolic syndrome (MS) is tightly associated with the oncogenesis and prognosis of endometrioid adenocarcinoma, but the underlying mechanism is unclear. Here, we studied the relation between the expression status of WW domain‐containing oxidoreductase (WWOX) and the clinicopathological features of endometrioid adenocarcinoma patients with ...
Yan Shen, Leilei Gao, Shanshan Jiang, Jinwei Liu, Weiye Cheng, Huafeng Shou   +5 more
openaire   +2 more sources

Loss of WW domain-containing oxidoreductase expression in the progression and development of gastric carcinoma: clinical and histopathologic correlations

Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin, 2010
The purpose of this study is to investigate the role of the WW domain-containing oxidoreductase (WWOX) tumor suppressor that maps to the common fragile site FRA16D (16q23.3-24.1) during the development of gastric carcinoma (GC), we examined the altered expression of WWOX in GC cell lines and tissue samples as well as the effects of restoration of the ...
Hiroshi Yokozaki
exaly   +3 more sources

MPP⁺‐induced neuronal death in rats involves tyrosine 33 phosphorylation of WW domain‐containing oxidoreductase WOX1

European Journal of Neuroscience, 2008
AbstractWW domain‐containing oxidoreductase (named WWOX, FOR or WOX1) is a pro‐apoptotic protein and tumor suppressor. Animals treated with dopaminergic neurotoxin 1‐methyl‐4‐phenyl‐pyridinium (MPP+) develop Parkinson's disease (PD)‐like symptoms. Here we investigated whether WOX1 is involved in MPP+‐induced neurodegeneration.
Chen-Peng, Lo, Li-Jin, Hsu, Meng-Yen, Li, Se-Yei, Hsu, Jih-Ing, Chuang, Ming-Shu, Tsai, Sing-Ru, Lin, Nan-Shan, Chang, Shur-Tzu, Chen   +8 more
openaire   +4 more sources

WW domain-containing oxidoreductase regulates T cell activation 9024

The Journal of Immunology
Abstract Description   T cell-mediated immunity is a central component in the immune system. Stimulation of T cell receptor (TCR) is crucial for T cell activation and proliferation. Human WWOX gene resides within a common chromosomal fragile site FRA16D and encodes a tumor suppressor WW domain ...
openaire   +1 more source