Results 181 to 190 of about 5,535 (193)
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Abstract LB-091: Tumor suppressor WW domain-containing oxidoreductase controls epidermal keratinocyte growth

Cancer Research, 2019
Abstract Human fragile WWOX gene encodes a candidate tumor suppressor WW domain-containing oxidoreductase. Ectopically overexpressed WWOX protein induces apoptosis in cancer cells and suppresses tumor growth both in vitro and in vivo. Functional suppression of WWOX by antisense mRNA, dominant negatives, and small interfering RNA protects
openaire   +1 more source

WW domain containing oxidoreductase gene expression is altered in non-small cell lung cancer.

Cancer research, 2003
WWOX (WW domain containing oxidoreductase), a putative tumor suppressor gene that maps to the common fragile site FRA16D on chromosome 16q23.3-24.1, is altered in breast, esophageal, and ovarian cancer. Because the FRA3B/FHIT locus at 3p14.2 is a preferential target for genetic changes caused by tobacco smoke, we intended to evaluate the status of the ...
YENDAMURI S.   +8 more
openaire   +2 more sources

Abstract 2839: The functional role of tumor suppressor WW domain-containing oxidoreductase in maintaining genome integrity

Cancer Research
The induction of DNA damage response (DDR) to ensure accurate duplication of genetic information during DNA replication is crucial for maintaining genome integrity. Cellular senescence is a DDR mechanism that prevents the proliferation of cells with deleterious DNA damage to avoid mitotic anomalies and inheritance of the damage over cell generations. A
openaire   +1 more source

Structural insights into the role of the WW2 domain on tandem WW–PPxY motif interactions of oxidoreductase WWOX

Journal of Biological Chemistry, 2022
Tomer Tsaban   +2 more
exaly  

NADPH–cytochrome P450 oxidoreductase: Prototypic member of the diflavin reductase family

Archives of Biochemistry and Biophysics, 2012
Jung-Ja P Kim
exaly  

The heme domain of cellobiose oxidoreductase: a one-electron reducing system

Biochimica Et Biophysica Acta - Bioenergetics, 2003
Christina Divne   +2 more
exaly  

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