Results 231 to 240 of about 169,270 (280)

Advances in GPCRs Associated With Wnt Signaling Within the Auditory System

Medicine Bulletin, EarlyView.
ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang, Changling Xu, Jiangang Fan, Renjie Chai   +3 more
wiley   +1 more source

The Impact of Participation in the Parkinson's Pals Program on Psychosocial Symptoms in Parkinson's Disease: An Unblinded Feasibility Study

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Persons with Parkinson's disease (pwPD) frequently experience psychosocial symptoms that are inadequately addressed by traditional clinical approaches. Objectives To evaluate the impact of Parkinson's Pals, a student‐led virtual, intergenerational program, on psychosocial symptoms in pwPD and student knowledge.
Jaskeerat Gujral, Udit Garg, Om H. Gandhi, Lynn Eickholt, Whitley W. Aamodt   +4 more
wiley   +1 more source

Depletion of microglial compensation in glial network: Disease‐associated response dynamics in the revised amyloid hypothesis

Neuroprotection, EarlyView.
The critical transition from amyloid pathology to irreversible neuronal loss in Alzheimer's disease hinges on the microglial response. This review aims to systematize the patterns of how microglia react within the glial context. Abstract Microglia mount coordinated, stage‐dependent compensatory programs in response to early amyloid β (Aβ) accumulation ...
Songtao Lei, Zixuan Huang, Wen Wang, Yan Meng   +3 more
wiley   +1 more source

Globalizing Comparative Public Administration With Integrative Contextualization: State Autonomy in the Developmental Path of Hong Kong and Singapore

Public Administration and Development, EarlyView.
ABSTRACT The lack of a common variable for comparison has been a major obstacle to the development of Comparative Public Administration (CPA). State autonomy enables an integrative contextualization approach, allowing both the analysis of contextual individual country experiences and the generation of generalized comparable knowledge.
Wilson Wong
wiley   +1 more source

Evidence map and gap analysis of metabolic change in pediatric growth hormone deficiency treated with growth hormone

Pediatric Investigation, EarlyView.
This evidence map of 63 studies (n = 6158) showed growth hormone therapy in children with growth hormone deficiency has neutral glucose effects, mixed lipid outcomes, potential benefits for bone mineral density, bone mineral content, and parathyroid hormone, but generally no impact on thyroid function, body composition, or body mass index.
Wei Wu, Ningyi Song, Yue Zhao, Caiqi Du, Yuning Zhao, You Wu, Xiaoping Luo   +6 more
wiley   +1 more source

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension &Cirrhosis, EarlyView.
This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
wiley   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source

A synthetic eco‐evolutionary proposal for the conservation of wild relatives of the olive tree

PLANTS, PEOPLE, PLANET, EarlyView.
Societal Impact Statement Crop wild relatives (CWR) are valuable sources of genetic diversity for plant breeding. However, the identification of wild untapped genetic resources (i.e., unexploited in crops) is not always straightforward. We propose a methodology to guide the identification and conservation of these resources that integrates both genetic
Andrés Barea‐Márquez, Guillaume Besnard, Miguel González Ximénez‐Embún, Carlos García‐Verdugo, Concepción M. Diez, José Carlos Pérez‐Girón, Rafael Rubio de Casas   +6 more
wiley   +1 more source

Thin Fluoride Insulators for Improved 2D Transistors: From Deposition Methods to Recent Applications

physica status solidi (RRL) – Rapid Research Letters, EarlyView.
2D materials hold significant promise for next‐generation electronic and optoelectronic devices, but suitable gate dielectrics are still a challenge. Fluoride insulators, offering inert, dangling‐bond‐free surfaces, have recently emerged as strong candidates. This review covers recent publications on high‐quality fluoride thin‐film deposition and their
Behzad Dadashnia, Saeed Rasouli, Walter M. Weber, Daniele Nazzari   +3 more
wiley   +1 more source

UCanWBGT: urban street canyon heat stress calculation for weather and climate models

Quarterly Journal of the Royal Meteorological Society, EarlyView.
This work introduces UCanWBGT, a new model to calculate wet‐bulb globe temperature in an urban environment, suitable for use with weather and climate model data. We present the model, then verify its performance against observations made in the streets of Paris during heatwave conditions.
Jonathan K. P. Shonk, Lewis P. Blunn, Vinod Kumar, Jean Wurtz, Valéry Masson   +4 more
wiley   +1 more source