Results 91 to 100 of about 6,450 (234)

Long‐term outcomes of a cohort of patients with pharmacoresistant neonatal epilepsy and negative brain MRI

Epilepsia Open, Volume 10, Issue 5, Page 1605-1616, October 2025.
Abstract Objective Neonatal seizures initiate the onset of epilepsy in less than 20% of cases. Establishing accurate and prompt diagnosis for precision medicine, offering tailored care, and informing families about neurodevelopmental prognosis represents a significant challenge.
Thibault Beretti, William Rozalen, Laurent Villard, Florence Riccardi, Geraldine Daquin, Anne Lepine, Nathalie Villeneuve, Mathieu Milh, Béatrice Desnous   +8 more
wiley   +1 more source

WWOX drives UV/cold shock‐induced bubbling cell death whereas without WWOX cells pop out

The FASEB Journal, 2019
Bubbling cell death (BCD) is known as release of an enlarging nuclear bubble from the surface of each cell at room temperature or lower post exposure of the cells to UV irradiation and cold shock. BCD concerns the severity of frostbite and UV. However, the molecular mechanism is largely unknown.
Nan‐Shan Chang, Cheng‐Chang Tsai, Hamm‐Ming Sheu   +2 more
openaire   +1 more source

Molecular landscapes of glioblastoma cell lines revealed a group of patients that do not benefit from WWOX tumor suppressor expression

Frontiers in Neuroscience, 2023
IntroductionGlioblastoma (GBM) is notorious for its clinical and molecular heterogeneity, contributing to therapeutic failure and a grim prognosis. WWOX is one of the tumor suppressor genes important in nervous tissue or related pathologies, which was ...
Żaneta Kałuzińska-Kołat, Damian Kołat, Katarzyna Kośla, Elżbieta Płuciennik, Andrzej K. Bednarek   +4 more
doaj   +1 more source

FANCD2 facilitates replication through common fragile sites [PDF]

, 2016
Common fragile sites (CFSs) are genomic regions that are unstable under conditions of replicative stress. Although the characteristics of CFSs that render them vulnerable to stress are mainly associated with replication, the cellular pathways that ...
Aguilera López, Andrés, García Rubio, María Luisa, Herrera Moyano, Emilia, Madireddy, Advaitha, Olson, Susan, Owen, Nichole   +5 more
core   +1 more source

Ancestral genomic functional differences in oligodendroglia: implications for Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.
Abstract INTRODUCTION This study investigates ancestry‐specific changes in induced pluripotent stem cell (iPSC)‐derived oligodendroglia genomic regulation in Alzheimer's disease (AD), addressing diversity gaps by including African, Amerindian, and European ancestries in the analysis. METHODS We generated 12 iPSC lines from AD patients and controls with
Aura M. Ramirez, Luciana Bertholim Nasciben, Sofia Moura, Lauren Coombs, Farid Rajabli, Brooke A. DeRosa, Patrice L. Whitehead, Larry D. Adams, Takiyah D. Starks, Pedro R. Mena, Maryenela Illanes‐Manrique, Sergio Tejada, Goldie S. Byrd, Allison Caban‐Holt, Michael L Cuccaro, Katalina McInerney, Mario R. Cornejo‐Olivas, Briseida E. Feliciano‐Astacio, Liyong Wang, Maria C. Robayo, Wanying Xu, Fulai Jin, Margaret A. Pericak‐Vance, Anthony J. Griswold, Juan I. Young, Derek M. Dykxhoorn, Jeffery M. Vance   +26 more
wiley   +1 more source

Intermediate Conductance Calcium‐Dependent Potassium Channel (KCa3.1) Interacting Proteins Using Turboid‐Based Proximity Labeling Technology: Insights Into Interactome and Related Signaling Pathways in Pancreatic Tumors

Journal of Cellular Physiology, Volume 240, Issue 9, September 2025.
ABSTRACT KCa3.1 ion channel is a calcium‐activated potassium channel expressed in various tissues, showing dual localization to the plasma membrane and to mitochondria. This channel is highly expressed in numerous cancers and has been implicated in the regulation of proliferation and migration.
Veronica Carpanese, Soha Sadeghi, Luca Matteo Todesca, Ildikò Szabò, Vanessa Checchetto   +4 more
wiley   +1 more source

WWOX Drives T Leukemia Cell Maturation via IκBα/WWOX/ERK Signal Pathway

Journal of Tumor Research, 2017
Forced differentiation therapy has been shown to be effective in suppressing promyelocytic leukemia cell growth and other types of cancer cells in patients. A combination of calcium ionophore and phorbol ester is effective in inducing terminal maturation of T-cell acute lymphoblastic leukemia (T-ALL), in which it requires the signaling of IκBα/WWOX/ERK.
openaire   +1 more source

Dissecting Intra-Tumor Heterogeneity by the Analysis of Copy Number Variations in Single Cells: The Neuroblastoma Case Study [PDF]

, 2019
Tumors often show intra-tumor heterogeneity because of genotypic differences between all the cells that compose it and that derive from it. Recent studies have shown significant aspects of neuroblastoma heterogeneity that may affect the diagnostic ...
Borrillo, Francesca, Cariati, Federica, D'Argenio, Valeria, Nunziato, Marcella, Shankar, Varun, Tomaiuolo, Rossella   +5 more
core   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3β-mediated epileptic seizure activity in mice

Acta Neuropathologica Communications, 2020
Human WWOX gene resides in the chromosomal common fragile site FRA16D and encodes a tumor suppressor WW domain-containing oxidoreductase. Loss-of-function mutations in both alleles of WWOX gene lead to autosomal recessive abnormalities in pediatric ...
Ya-Yun Cheng, Ying-Tsen Chou, Feng-Jie Lai, Ming-Shiou Jan, Tsung-Hao Chang, I-Ming Jou, Pei-Shiuan Chen, Jui-Yen Lo, Shiang-Suo Huang, Nan-Shan Chang, Yung-Tsai Liou, Po-Chih Hsu, Hui-Ching Cheng, Yee-Shin Lin, Li-Jin Hsu   +14 more
doaj   +1 more source