Results 11 to 20 of about 6,450 (234)
Neonatal neuronal WWOX gene therapy rescues Wwox null phenotypes [PDF]
EMBO Molecular Medicine, 2021 WW domain‐containing oxidoreductase (WWOX) is an emerging neural gene‐regulating homeostasis of the central nervous system. Germline biallelic mutations in WWOX cause WWOX‐related epileptic encephalopathy (WOREE) syndrome and spinocerebellar ataxia and ...
Srinivasarao Repudi +4 more
doaj +8 more sources
Association of WWOX Gene Expression with Chronic Lymphocytic Leukemia
Namık Kemal Tıp Dergisi, 2020 Aim:The WW domain-containing oxidoreductase (WWOX) gene is located on chromosome 16q23.3-q24.1 and contains the common chromosomal fragile site, FRA16D. The WWOX gene encodes a Wwox tumor suppressor protein with a molecular weight of 46 kDa.
Halil HANCI +4 more
doaj +4 more sources
Frontiers in Genetics, 2023 Introduction: The discovery of non-coding RNA (ncRNA) dates back to the pre-genomics era, but the progress in this field is still dynamic and leverages current post-genomics solutions.
Damian Kołat +5 more
doaj +3 more sources
WWOX Modulates ROS-Dependent Senescence in Bladder Cancer
Molecules, 2022 The tumor-suppressor gene, WW domain-containing oxidoreductase (WWOX), has been found to be lost in various types of cancers. ROS result as a tightly regulated signaling process for the induction of cell senescence.
Ching-Wen Liu +4 more
doaj +3 more sources
WWOX tuning of oleic acid signaling orchestrates immunosuppressive macrophage polarization and sensitizes hepatocellular carcinoma to immunotherapy [PDF]
Journal for ImmunoTherapy of CancerBackground Immune checkpoint inhibitors (ICIs) are therapeutically effective for hepatocellular carcinoma (HCC) but are individually selective. This study examined the role of specific common fragile sites (CFSs) related gene in HCC immunotherapy.Methods
Min Xu +13 more
doaj +2 more sources
WWOX Phosphorylation, Signaling, and Role in Neurodegeneration [PDF]
Frontiers in Neuroscience, 2018 Homozygous null mutation of tumor suppressor WWOX/Wwox gene leads to severe neural diseases, metabolic disorders and early death in the newborns of humans, mice and rats.
Chan-Chuan Liu +14 more
doaj +3 more sources
Endogenous Processes Underlying Clock-Like Mutational Signatures. [PDF]
Genes Chromosomes CancerABSTRACT Wellcome Trust scientists have shown that “mutational signatures” in specific nucleotide contexts accumulate in genomes of mammalian tissues, providing clues to underlying causes of specific signatures. Analysis of cancer genomes has identified more than 50 single‐base substitution (SBS) signatures, with SBS1, SBS5, and SBS40 linked to aging ...
Druck T +4 more
europepmc +2 more sources
Folate Interaction With Genetic Risk for Neural Tube Defects Among Infants in Bangladesh. [PDF]
Birth Defects ResABSTRACT Background Neural tube defects such as spina bifida (SB) are congenital anomalies associated with significant morbidity and mortality worldwide. Environmental factors, particularly folate, modify SB risk. Based on recurrence rates of SB within families, genetic risk also contributes to SB development.
Mondragon-Estrada E +13 more
europepmc +2 more sources
Unveiling the relationship between WWOX and BRCA1 in mammary tumorigenicity and in DNA repair pathway selection [PDF]
Cell Death DiscoveryBreast cancer is the leading cause of cancer-related deaths in women worldwide, with the basal-like or triple-negative breast cancer (TNBC) subtype being particularly aggressive and challenging to treat. Understanding the molecular mechanisms driving the
Tirza Bidany-Mizrahi +5 more
doaj +2 more sources
Frontiers in Oncology, 2022 BackgroundPrevious studies have identified three single nucleotide polymorphisms (SNPs): GALNT14-rs9679162, WWOX-rs13338697 and rs6025211. Their genotypes are associated with therapeutic outcomes in hepatocellular carcinoma (HCC).
Yu-De Chu +6 more
doaj +1 more source