Results 11 to 20 of about 6,282 (233)

Neonatal neuronal WWOX gene therapy rescues Wwox null phenotypes [PDF]

EMBO Molecular Medicine, 2021
WW domain‐containing oxidoreductase (WWOX) is an emerging neural gene‐regulating homeostasis of the central nervous system. Germline biallelic mutations in WWOX cause WWOX‐related epileptic encephalopathy (WOREE) syndrome and spinocerebellar ataxia and ...
Srinivasarao Repudi, Irina Kustanovich, Sara Abu‐Swai, Shani Stern, Rami I Aqeilan   +4 more
doaj   +6 more sources

WWOX and Its Binding Proteins in Neurodegeneration [PDF]

Cells, 2021
WW domain-containing oxidoreductase (WWOX) is known as one of the risk factors for Alzheimer’s disease (AD), a neurodegenerative disease. WWOX binds Tau via its C-terminal SDR domain and interacts with Tau phosphorylating enzymes ERK, JNK, and GSK-3β ...
Che-Yu Hsu, Kuan-Ting Lee, Tzu-Yu Sun, Chun-I. Sze, Shenq-Shyang Huang, Li-Jin Hsu, Nan-Shan Chang   +6 more
doaj   +5 more sources

Normal cells repel WWOX-negative or -dysfunctional cancer cells via WWOX cell surface epitope 286-299 [PDF]

Communications Biology, 2021
Yu-An Chen et al characterize the role of cell surface epitopes of the tumor suppressor protein WWOX in cell–cell recognition. The find that cells expressing functional WWOX, repel cancer cells which express dysfunctional WWOX or lack this protein, in a ...
Yu-An Chen, Yong-Da Sie, Tsung-Yun Liu, Hsiang-Ling Kuo, Pei-Yi Chou, Yu-Jie Chen, Kuan-Ting Lee, Pin-Jun Chen, Shur-Tzu Chen, Nan-Shan Chang   +9 more
doaj   +4 more sources

Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene. [PDF]

PLoS ONE, 2009
WWOX, the gene that spans the second most common human chromosomal fragile site, FRA16D, is inactivated in multiple human cancers and behaves as a suppressor of tumor growth.
John H Ludes-Meyers, Hyunsuk Kil, Jan Parker-Thornburg, Donna F Kusewitt, Mark T Bedford, C Marcelo Aldaz   +5 more
doaj   +4 more sources

WWOX Phosphorylation, Signaling, and Role in Neurodegeneration [PDF]

Frontiers in Neuroscience, 2018
Homozygous null mutation of tumor suppressor WWOX/Wwox gene leads to severe neural diseases, metabolic disorders and early death in the newborns of humans, mice and rats.
Chan-Chuan Liu, Chan-Chuan Liu, Pei-Chuan Ho, I.-Ting Lee, Yu-An Chen, Chun-Hsien Chu, Chih-Chuan Teng, Sheng-Nan Wu, Chun-I. Sze, Chun-I. Sze, Ming-Fu Chiang, Nan-Shan Chang, Nan-Shan Chang, Nan-Shan Chang, Nan-Shan Chang   +14 more
doaj   +4 more sources

WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome [PDF]

BMC Cancer, 2005
Background The putative tumor suppressor WWOX gene spans the common chromosomal fragile site 16D (FRA16D) at chromosome area 16q23.3-24.1. This region is a frequent target for loss of heterozygosity and chromosomal rearrangement in ovarian, breast ...
Liu Jinsong, Godwin Andrew K, Klein-Szanto Andres JP, Page Robert, Kil Hyunsuk, Abba Martín C, Ludes-Meyers John H, Rosen Daniel G, Nunez María I, Mills Gordon B, Aldaz C Marcelo   +10 more
doaj   +5 more sources

Unveiling the relationship between WWOX and BRCA1 in mammary tumorigenicity and in DNA repair pathway selection [PDF]

Cell Death Discovery
Breast cancer is the leading cause of cancer-related deaths in women worldwide, with the basal-like or triple-negative breast cancer (TNBC) subtype being particularly aggressive and challenging to treat. Understanding the molecular mechanisms driving the
Tirza Bidany-Mizrahi, Aya Shweiki, Kian Maroun, Lina Abu-Tair, Bella Mali, Rami I. Aqeilan   +5 more
doaj   +2 more sources

Introduction to a Thematic Issue for WWOX [PDF]

Experimental Biology and Medicine, 2015
Since its discovery in 2000, WW domain-containing oxidoreductase (WWOX, FOR or WOX1) has been considered as a tumor suppressor protein. Global research focus has been aimed mainly toward this direction. In this thematic issue, updated information has been collected regarding the structure, function and signaling of WWOX, along with its critical role ...
Nan‐Shan Chang
openalex   +3 more sources

WWOX, A NEW POTENTIAL TUMOR SUPPRESSOR GENE [PDF]

Biomedical Papers, 2007
WWOX (WW domain-containing oxidoreductase) gene, located on chromosome 16q 23.3-24.1 in the region recognized as the common fragile site FRA16D is considered to be a tumor suppressor gene involved in various cancers: breast, ovarian, prostate, esophageal, lung, pancreatic, gastric and hepatic.
Renata Héžová, Jiří Ehrmann, Zdeněk Kolář   +2 more
openalex   +4 more sources

WWOX-related epileptic encephalopathy caused by a novel mutation in the WWOX gene: a case report. [PDF]

Front Pediatr
BackgroundWWOX-related epileptic encephalopathy is an autosomal recessive disorder caused by mutations in the WW-containing oxidoreductase gene, characterized by the onset of refractory seizures in infants. Early-onset epilepsy, electroencephalography abnormalities, and developmental delay or degeneration are the main clinical manifestations.
Feng D, Li Y, Zhang YT, Song YJ, Qin DY, Wang F.   +5 more
europepmc   +4 more sources