Results 21 to 30 of about 6,450 (234)
Cells, 2022 Tumor suppressor WWOX inhibits cancer growth and retards Alzheimer’s disease (AD) progression. Supporting evidence shows that the more strongly WWOX binds intracellular protein partners, the weaker is cancer cell growth in vivo.
Tsung-Yun Liu +7 more
doaj +1 more source
Loss of wwox expression in zebrafish embryos causes edema and alters Ca2+ dynamics [PDF]
PeerJ, 2015 We investigated the role of the WW domain-containing oxidoreductase (wwox) gene in the embryonic development of zebrafish, with particular emphasis on intracellular Ca2+ dynamics because Ca2+ is an important intracellular messenger.
Yusuke Tsuruwaka +2 more
doaj +2 more sources
Wwox inactivation enhances mammary tumorigenesis [PDF]
Oncogene, 2011 Breast cancer is the leading cause of cancer-related death in women worldwide. Expression of the WWOX tumor suppressor is absent or reduced in a large proportion of breast tumors suggesting that loss of WWOX may contribute to breast tumorigenesis. Wwox-deficient mice die by 3-4 weeks of age precluding adult tumor analysis.
S K, Abdeen +9 more
openaire +2 more sources
The degree of segmental aneuploidy measured by total copy number abnormalities predicts survival and recurrence in superficial gastroesophageal adenocarcinoma [PDF]
, 2014 Background: Prognostic biomarkers are needed for superficial gastroesophageal adenocarcinoma (EAC) to predict clinical outcomes and select therapy. Although recurrent mutations have been characterized in EAC, little is known about their clinical and ...
A Janssen +67 more
core +10 more sources
BMC Veterinary Research, 2020 Background The WW domain-containing oxidoreductase (WWOX) tumor suppressor gene is frequently lost in a variety of solid and hematopoietic malignancies in humans. Dysregulation of WWOX has been implicated as playing a key role in tumor cell survival, DNA
Rebecca Makii +7 more
doaj +1 more source
Conditional Wwox deletion in mouse mammary gland by means of two Cre recombinase approaches. [PDF]
PLoS ONE, 2012 Loss of WWOX expression has been reported in many different cancers including breast cancer. Elucidating the function of this gene in adult tissues has not been possible with full Wwox knockout models. Here we characterize the first conditional models of
Brent W Ferguson +6 more
doaj +1 more source
Mouse Models of Osteosarcoma: Unraveling Disease Mechanisms and Accelerating Drug Discovery and Development. [PDF]
Cancer Rep (Hoboken)ABSTRACT Background Osteosarcoma is the most frequent primary bone malignancy, affecting mainly children, adolescents, and young adults. For the past 40 years, improvements in the survival of patients with osteosarcoma have been minimal, primarily as a consequence of the lack of systemic therapy options beyond traditional cytotoxic agents.
Haney SL, Holstein SA.
europepmc +2 more sources
WWOX loss activates aerobic glycolysis [PDF]
Molecular & Cellular Oncology, 2014 Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis-a state known as "aerobic glycolysis." Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch.
Abu-Remaileh, Muhannad +2 more
openaire +2 more sources
Neurological Disorders Associated with WWOX Germline Mutations—A Comprehensive Overview
Cells, 2021 The transcriptional regulator WW domain-containing oxidoreductase (WWOX) is a key player in a number of cellular and biological processes including tumor suppression. Recent evidence has emerged associating WWOX with non-cancer disorders.
Ehud Banne +10 more
doaj +1 more source
Tumor Suppressor WWOX Contributes to the Elimination of Tumorigenic Cells in Drosophila melanogaster. [PDF]
PLoS ONE, 2015 WWOX is a >1 Mb gene spanning FRA16D Common Chromosomal Fragile Site, a region of DNA instability in cancer. Consequently, altered WWOX levels have been observed in a wide variety of cancers. In vitro studies have identified a large number and variety of
Louise V O'Keefe +3 more
doaj +1 more source