Results 21 to 30 of about 6,282 (233)
Cells, 2022 Tumor suppressor WWOX inhibits cancer growth and retards Alzheimer’s disease (AD) progression. Supporting evidence shows that the more strongly WWOX binds intracellular protein partners, the weaker is cancer cell growth in vivo.
Tsung-Yun Liu +7 more
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WWOX-Related Neurodevelopmental Disorders: Models and Future Perspectives [PDF]
Cells, 2021 The WW domain-containing oxidoreductase (WWOX) gene was originally discovered as a putative tumor suppressor spanning the common fragile site FRA16D, but as time has progressed the extent of its pleiotropic function has become apparent. At present, WWOX is a major source of interest in the context of neurological disorders, and more specifically ...
Daniel J. Steinberg, Rami I. Aqeilan
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Loss of wwox expression in zebrafish embryos causes edema and alters Ca2+ dynamics [PDF]
PeerJ, 2015 We investigated the role of the WW domain-containing oxidoreductase (wwox) gene in the embryonic development of zebrafish, with particular emphasis on intracellular Ca2+ dynamics because Ca2+ is an important intracellular messenger.
Yusuke Tsuruwaka +2 more
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WWOX in biological control and tumorigenesis [PDF]
Journal of Cellular Physiology, 2007 AbstractThe WW domain‐containing oxidoreductase (WWOX) gene is located at 16q23.1–16q23.2, a region that spans the second most common human fragile site, FRA16D. The WWOX protein contains two N‐terminal WW domains and a central short chain oxidoreductase‐like domain.
Rami I. Aqeilan, Carlo M. Croce
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BMC Veterinary Research, 2020 Background The WW domain-containing oxidoreductase (WWOX) tumor suppressor gene is frequently lost in a variety of solid and hematopoietic malignancies in humans. Dysregulation of WWOX has been implicated as playing a key role in tumor cell survival, DNA
Rebecca Makii +7 more
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The WWOX gene in brain development and pathology [PDF]
Experimental Biology and Medicine, 2020 Shortly after its discovery in 2000, WWOX was hailed as a tumor suppressor gene. In subsequent years of research, this function was confirmed indisputably. Majority of tumors show high rate of loss of heterozygosity and decreased expression of WWOX.
K Kośla, Ż Kałuzińska, AK Bednarek
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WWOX Drives T Leukemia Cell Maturation via IκBα/WWOX/ERK Signal Pathway
Journal of Tumor Research, 2017 Forced differentiation therapy has been shown to be effective in suppressing promyelocytic leukemia cell growth and other types of cancer cells in patients. A combination of calcium ionophore and phorbol ester is effective in inducing terminal maturation of T-cell acute lymphoblastic leukemia (T-ALL), in which it requires the signaling of IκBα/WWOX/ERK.
Nan‐Shan Chang
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Functional genetic variant of WW domain-containing oxidoreductase (WWOX) gene is associated with hepatocellular carcinoma risk. [PDF]
PLoS ONE, 2017 BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. Human WW domain-containing oxidoreductase (WWOX) gene has been identified as a tumor suppressor gene in multiple cancers.
Hsiang-Lin Lee +5 more
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The cancer gene WWOX behaves as an inhibitor of SMAD3 transcriptional activity via direct binding [PDF]
, 2013 Background: The WW domain containing protein WWOX has been postulated to behave as a tumor suppressor in breast and other cancers. Expression of this protein is lost in over 70% of ER negative tumors.
Abba, Martín Carlos +6 more
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Neurological Disorders Associated with WWOX Germline Mutations—A Comprehensive Overview
Cells, 2021 The transcriptional regulator WW domain-containing oxidoreductase (WWOX) is a key player in a number of cellular and biological processes including tumor suppression. Recent evidence has emerged associating WWOX with non-cancer disorders.
Ehud Banne +10 more
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