Mechanics and dynamics of X-chromosome pairing at X inactivation. [PDF]
PLoS Computational Biology, 2008 At the onset of X-chromosome inactivation, the vital process whereby female mammalian cells equalize X products with respect to males, the X chromosomes are colocalized along their Xic (X-inactivation center) regions.
Antonio Scialdone, Mario Nicodemi
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Transcriptional changes in response to X chromosome dosage in the mouse: implications for X inactivation and the molecular basis of Turner Syndrome [PDF]
BMC Genomics, 2010 Background X monosomic mice (39,XO) have a remarkably mild phenotype when compared to women with Turner syndrome (45,XO). The generally accepted hypothesis to explain this discrepancy is that the number of genes on the mouse X chromosome which escape X ...
Sargent Carole A +6 more
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Heterogeneous X Inactivation in Trophoblastic Cells of Human Full-Term Female Placentas [PDF]
, 1999 In female mammalian cells, one of the two X chromosomes is inactivated to compensate for gene-dose effects, which would be otherwise doubled compared with that in male cells.
Leendert H. J. Looijenga +4 more
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Explaining gender differences in caries: a multifactorial approach to a multifactorial disease. [PDF]
, 2010 Many studies have demonstrated that caries rates are higher in women than in men. This review attempts to provide an explanation for this trend by examining each factor which contributes to caries and how the factor differs in men and women. Evidence has
Ferraro, Maria, Vieira, Alexandre R
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The pattern of X-inactivation in Human X-linked Disorders and their Model Organisms: A literature review [PDF]
E3S Web of Conferences, 2020 X-inactivation is a strategy in female mammals aiming at maximizing gene inactivation of one single X chromosome in order to balance X dosage between males and females.
Zhou Yixin
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X chromosome inactivation during Drosophila spermatogenesis. [PDF]
PLoS Biology, 2007 Genes with male- and testis-enriched expression are under-represented on the Drosophila melanogaster X chromosome. There is also an excess of retrotransposed genes, many of which are expressed in testis, that have "escaped" the X chromosome and moved to ...
Winfried Hense +2 more
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Differentiation-dependent Requirement of Tsix long non-coding RNA in Imprinted X-chromosome Inactivation [PDF]
, 2014 Imprinted X-inactivation is a paradigm of mammalian transgenerational epigenetic regulation resulting in silencing of genes on the paternally-inherited X-chromosome.
Buttigieg, Emily +8 more
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Inexpensive protocol for single-cell X-chromosome inactivation analysis: Xist expression and H3K27me3 staining [PDF]
Письма в Вавиловский журнал генетики и селекции, 2022 The X-chromosome status is an important marker of mammalian cell embryonic differentiation. Both female X-chromosomes are transcriptionally active (Xa) at the blastocyst stage, then one of the X-chromosomes undergoes random inactivation (Xi).
Pristyazhnyuk I.E. +2 more
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X Inactivation Lessons from Differentiating Mouse Embryonic Stem Cells [PDF]
, 2015 X chromosome inactivation (XCI) is the dosage compensation mechanism that evolved in female mammals to correct the genetic imbalance of X-linked genes between sexes.
Andrea Cerase, Greta Pintacuda
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Activity map of the tammar X chromosome shows that marsupial X inactivation is incomplete and escape is stochastic [PDF]
, 2016 BACKGROUND: X chromosome inactivation is a spectacular example of epigenetic silencing. In order to deduce how this complex system evolved, we examined X inactivation in a model marsupial, the tammar wallaby (Macropus eugenii).
Al Nadaf, Shafagh +5 more
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