Results 21 to 30 of about 328,618 (261)

Rlim/Rnf12, Rex1, and X Chromosome Inactivation

Frontiers in Cell and Developmental Biology, 2019
RLIM/Rnf12 is an E3 ubiquitin ligase that has originally been identified as a transcriptional cofactor associated with LIM domain transcription factors.
Feng Wang, Ingolf Bach
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X-Inactivation: It Takes Two to Count [PDF]

Current Biology, 2008
Mammals balance X-linked gene dosage by silencing one X chromosome in female cells, a process that begins with counting the number of X chromosomes. Recent reports suggest homologous X chromosome pairing may be a prerequisite for silencing, providing a basis for counting by ensuring that silencing only occurs in cells with two X chromosomes.
Royce-Tolland, Morgan, Panning, Barbara
openaire   +2 more sources

Elastic dosage compensation by X-chromosome upregulation

Nature Communications, 2022
The concerted dynamics of X-chromosome upregulation and X-chromosome inactivation, which collectively balance X-chromosome expression, are not well understood.
Antonio Lentini, Huaitao Cheng, J. C. Noble, Natali Papanicolaou, Christos Coucoravas, Nathanael Andrews, Qiaolin Deng, Martin Enge, Björn Reinius   +8 more
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Normal X-inactivation mosaicism in corneas of heterozygous Flna^Dilp2/+ female mice--a model of human Filamin A (FLNA) diseases

BMC Research Notes, 2012
Background Some abnormalities of mouse corneal epithelial maintenance can be identified by the atypical mosaic patterns they produce in X-chromosome inactivation mosaics and chimeras. Human FLNA/+ females, heterozygous for X-linked, filamin A gene (FLNA)
Douvaras Panagiotis, Liu Weijia, Mort Richard L, McKie Lisa, West Katrine M, Cross Sally H, Morley Steven D, West John D   +7 more
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Large-scale population study of human cell lines indicates that dosage compensation is virtually complete. [PDF]

PLoS Genetics, 2008
X chromosome inactivation in female mammals results in dosage compensation of X-linked gene products between the sexes. In humans there is evidence that a substantial proportion of genes escape from silencing.
Colette M Johnston, Frances L Lovell, Daniel A Leongamornlert, Barbara E Stranger, Emmanouil T Dermitzakis, Mark T Ross   +5 more
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Genes that escape from X inactivation [PDF]

Human Genetics, 2011
To achieve a balanced gene expression dosage between males (XY) and females (XX), mammals have evolved a compensatory mechanism to randomly inactivate one of the female X chromosomes. Despite this chromosome-wide silencing, a number of genes escape X inactivation: in women about 15% of X-linked genes are bi-allelically expressed and in mice, about 3 ...
Joel B, Berletch, Fan, Yang, Jun, Xu, Laura, Carrel, Christine M, Disteche   +4 more
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A Comparative Analysis of Mouse Imprinted and Random X-Chromosome Inactivation

Epigenomes
The mammalian sexes are distinguished by the X and Y chromosomes. Whereas males harbor one X and one Y chromosome, females harbor two X chromosomes.
Rebecca M. Malcore, Sundeep Kalantry
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X chromosomes alternate between two states prior to random X-inactivation. [PDF]

PLoS Biology, 2006
Early in the development of female mammals, one of the two X chromosomes is silenced in half of cells and the other X chromosome is silenced in the remaining half. The basis of this apparent randomness is not understood.
Susanna Mlynarczyk-Evans, Morgan Royce-Tolland, Mary Kate Alexander, Angela A Andersen, Sundeep Kalantry, Joost Gribnau, Barbara Panning   +6 more
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Metaphase chromosome folds and X‐inactivation [PDF]

American Journal of Medical Genetics, 1987
AbstractTo evaluate the suggested nonrandom folding of Xql3‐q21 (center of Barr body condensation) of the inactivated X chromosomes, metaphases from nine subjects with or without X chromosome abnormalities (eight females and one male) were investigated with RBG‐staining.
Merlin G. Butler, Geeta M. Joseph, V. G. Dev, James F. Reynolds   +3 more
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SHOX and sex difference in height: a hypothesis

Endocrine Journal
The mean height is taller in males than in females, except for early teens. In this regard, previous studies have revealed that (1) distribution of the mean adult heights in subjects with disorders accompanied by discordance between sex chromosome ...
Tsutomu Ogata, Atsushi Hattori, Maki Fukami   +2 more
doaj   +1 more source