Activity map of the tammar X chromosome shows that marsupial X inactivation is incomplete and escape is stochastic [PDF]
, 2016 BACKGROUND: X chromosome inactivation is a spectacular example of epigenetic silencing. In order to deduce how this complex system evolved, we examined X inactivation in a model marsupial, the tammar wallaby (Macropus eugenii).
Al Nadaf, Shafagh +5 more
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Independent evolution of transcriptional inactivation on sex chromosomes in birds and mammals. [PDF]
PLoS Genetics, 2013 X chromosome inactivation in eutherian mammals has been thought to be tightly controlled, as expected from a mechanism that compensates for the different dosage of X-borne genes in XX females and XY males.
Alexandra M Livernois +4 more
doaj +1 more source
Systematic optimization of human pluripotent stem cells media using Design of Experiments. [PDF]
, 2015 Human pluripotent stem cells (hPSC) are used to study the early stages of human development in vitro and, increasingly due to somatic cell reprogramming, cellular and molecular mechanisms of disease.
Chailangkarn, Thanathom +2 more
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Characterisation of inactivation domains and evolutionary strata in human X chromosome through Markov segmentation. [PDF]
PLoS ONE, 2009 Markov segmentation is a method of identifying compositionally different subsequences in a given symbolic sequence. We have applied this technique to the DNA sequence of the human X chromosome to analyze its compositional structure.
Ashwin Kelkar +3 more
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LPS resistance of SPRET/Ei mice is mediated by Gilz, encoded by the Tsc22d3 gene on the X chromosome [PDF]
, 2013 Natural variation for LPS-induced lethal inflammation in mice is useful for identifying new genes that regulate sepsis, which could form the basis for novel therapies for systemic inflammation in humans.
Beaulieu E +12 more
core +2 more sources
Metaphase chromosome folds and X‐inactivation [PDF]
American Journal of Medical Genetics, 1987 AbstractTo evaluate the suggested nonrandom folding of Xql3‐q21 (center of Barr body condensation) of the inactivated X chromosomes, metaphases from nine subjects with or without X chromosome abnormalities (eight females and one male) were investigated with RBG‐staining.
Merlin G. Butler +3 more
openaire +2 more sources
Clinical expression of Menkes disease in females with normal karyotype
Orphanet Journal of Rare Diseases, 2012 Background Menkes Disease (MD) is a rare X-linked recessive fatal neurodegenerative disorder caused by mutations in the ATP7A gene, and most patients are males.
Møller Lisbeth +13 more
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A Primary Role for the Tsix lncRNA in Maintaining Random X-Chromosome Inactivation
Cell Reports, 2015 Differentiating pluripotent epiblast cells in eutherians undergo random X-inactivation, which equalizes X-linked gene expression between the sexes by silencing one of the two X-chromosomes in females. Tsix RNA is believed to orchestrate the initiation of
Srimonta Gayen +4 more
doaj +1 more source
Genes that escape from X inactivation [PDF]
Human Genetics, 2011 To achieve a balanced gene expression dosage between males (XY) and females (XX), mammals have evolved a compensatory mechanism to randomly inactivate one of the female X chromosomes. Despite this chromosome-wide silencing, a number of genes escape X inactivation: in women about 15% of X-linked genes are bi-allelically expressed and in mice, about 3 ...
Joel B, Berletch +4 more
openaire +2 more sources
Rlim/Rnf12, Rex1, and X Chromosome Inactivation
Frontiers in Cell and Developmental Biology, 2019 RLIM/Rnf12 is an E3 ubiquitin ligase that has originally been identified as a transcriptional cofactor associated with LIM domain transcription factors.
Feng Wang, Ingolf Bach
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