The X-inactivation trans-activator Rnf12 is negatively regulated by pluripotency factors in embryonic stem cells [PDF]
, 2011 X-inactivation, the molecular mechanism enabling dosage compensation in mammals, is tightly controlled during mouse early embryogenesis. In the morula, X-inactivation is imprinted with exclusive silencing of the paternally inherited X-chromosome.
Pablo Navarro +3 more
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X chromosome inactivation during Drosophila spermatogenesis. [PDF]
PLoS Biology, 2007 Genes with male- and testis-enriched expression are under-represented on the Drosophila melanogaster X chromosome. There is also an excess of retrotransposed genes, many of which are expressed in testis, that have "escaped" the X chromosome and moved to ...
Winfried Hense +2 more
doaj +1 more source
Inexpensive protocol for single-cell X-chromosome inactivation analysis: Xist expression and H3K27me3 staining [PDF]
Письма в Вавиловский журнал генетики и селекции, 2022 The X-chromosome status is an important marker of mammalian cell embryonic differentiation. Both female X-chromosomes are transcriptionally active (Xa) at the blastocyst stage, then one of the X-chromosomes undergoes random inactivation (Xi).
Pristyazhnyuk I.E. +2 more
doaj +1 more source
Human Naive Pluripotent Stem Cells Model X Chromosome Dampening and X Inactivation [PDF]
, 2017 Naive human embryonic stem cells (hESCs) can be derived from primed hESCs or directly from blastocysts, but their X chromosome state has remained unresolved.
Bonora, Giancarlo +10 more
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Differentiation-dependent Requirement of Tsix long non-coding RNA in Imprinted X-chromosome Inactivation [PDF]
, 2014 Imprinted X-inactivation is a paradigm of mammalian transgenerational epigenetic regulation resulting in silencing of genes on the paternally-inherited X-chromosome.
Buttigieg, Emily +8 more
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JCRPE, 2019 Borjeson-Forssman-Lehmann syndrome (BFLS) is a rare X-linked disease caused by PHF6 mutations. Classic BFLS has been associated with intellectual disability (ID), developmental delay (DD), obesity, epilepsy, typical facial features and anomalies of ...
Xia Zhang +9 more
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PLoS ONE, 2014 In rodent female mammals, there are two forms of X-inactivation - imprinted and random which take place in extraembryonic and embryonic tissues, respectively.
Evgeniya A Vaskova +7 more
doaj +1 more source
Genomic environment predicts expression patterns on the human inactive X chromosome. [PDF]
PLoS Genetics, 2006 What genomic landmarks render most genes silent while leaving others expressed on the inactive X chromosome in mammalian females? To date, signals determining expression status of genes on the inactive X remain enigmatic despite the availability of ...
Laura Carrel +5 more
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X Inactivation Lessons from Differentiating Mouse Embryonic Stem Cells [PDF]
, 2015 X chromosome inactivation (XCI) is the dosage compensation mechanism that evolved in female mammals to correct the genetic imbalance of X-linked genes between sexes.
Andrea Cerase, Greta Pintacuda
core +1 more source
Explaining gender differences in caries: a multifactorial approach to a multifactorial disease. [PDF]
, 2010 Many studies have demonstrated that caries rates are higher in women than in men. This review attempts to provide an explanation for this trend by examining each factor which contributes to caries and how the factor differs in men and women. Evidence has
Ferraro, Maria, Vieira, Alexandre R
core +4 more sources