Results 71 to 80 of about 1,203,775 (345)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
ZnO Nanowire Cold Cathode Hemispherical X‐Ray Sources
Advanced Electronic MaterialsCurved or spherical X‐ray sources are significant for use in intraoperative radiotherapy, adaptive static medical imaging, and high‐throughput industrial inspection, but they are hard to achieve using traditional thermionic cathode point electron sources.
Zhipeng Zhang +6 more
doaj +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
A Comprehensive Comparison of Spin-up and Spin-down Episodes of 4U 1538-522 Observed with NuSTAR
The Astrophysical Journal4U 1538-522 is a persistent high-mass X-ray binary that exhibits secular spin evolution. In 2019, it underwent a torque reversal from spinning up to spinning down.
Yongfeng Hu, Long Ji, Cong Yu, Lili Yang
doaj +1 more source
Globular Cluster X-Ray Sources [PDF]
Highlights of Astronomy, 1977 The discoveries of both steady and bursting X-ray sources in globular clusters have made them as interesting for high energy astrophysics and X-ray astronomy as they were for unlocking galactic structure in Shapley’ s day. Globular clusters are massive (˜ 105M⊙) spherical clusters of primarily low mass (⋞0.8 M⊙) evolved stars and may be the oldest ...
openaire +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Two Models for the Orbital Modulation of Gamma Rays in Cyg X-3
The Astrophysical JournalWe model the currently available γ -ray data on Cyg X-3 from the Fermi Large Area Telescope. Thanks to Cyg X-3’s very strong γ -ray activity during 2018–2021, the data quality has significantly improved.
Anton Dmytriiev +4 more
doaj +1 more source
The stability of subducted glaucophane with the Earth’s secular cooling
Nature Communications, 2021 Along the cold subduction geotherm, glaucophane remains stable down to pressure and temperature (P–T) conditions of ca. 240 km depth, whereas under the warm subduction geotherm, it dehydrates and breaks down into pyroxenes and silica between ca.
Yoonah Bang +13 more
doaj +1 more source
Synchrotron light source X-ray detection with Low-Gain Avalanche Diodes [PDF]
, 2023 S. M. Mazza +16 more
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Compact Binary X-Ray Sources [PDF]
International Astronomical Union Colloquium, 1986 AbstractCompact binary X-ray sources include white dwarfs, neutron stars, and black holes that are accreting matter from a companion star. The X-ray emission from these systems is produced by the accreting matter as it flows through an accretion disk and strikes the surface of the compact object.
openaire +1 more source