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The human inactive X chromosome modulates expression of the active X chromosome [PDF]
Cell Genomics, 2023 Summary: The “inactive” X chromosome (Xi) has been assumed to have little impact, in trans, on the “active” X (Xa). To test this, we quantified Xi and Xa gene expression in individuals with one Xa and zero to three Xis.
Adrianna K. San Roman +21 more
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Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome
Nature Communications, 2016 It is unclear how often genetic mosaicism of chromosome X arises. Here, the authors examine women with cancer and cancer-free controls and show that X chromosome mosaicism occurs more frequently than on autosomes, especially on the inactive X chromosome,
Mitchell J. Machiela +175 more
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X chromosome: expression and escape. [PDF]
PLoS Genetics, 2009 Although there are some obvious differences between the X chromosome and the autosomes—such as the X chromosome being present in only one copy in males—the two types of chromosome are remarkably similar in their cytological appearance and gene density [1]. Genomic and transcriptomic studies of Drosophila, however, have revealed two major differences in
John Parsch
doaj +6 more sources
The X chromosome and sex-specific effects in infectious disease susceptibility
Human Genomics, 2019 The X chromosome and X-linked variants have largely been ignored in genome-wide and candidate association studies of infectious diseases due to the complexity of statistical analysis of the X chromosome.
Haiko Schurz +5 more
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The X chromosome and male infertility [PDF]
Human Genetics, 2019 The X chromosome is a key player in germ cell development, as has been highlighted for males in previous studies revealing that the mammalian X chromosome is enriched in genes expressed in early spermatogenesis.
M. Vockel +3 more
semanticscholar +10 more sources
A ROLE FOR CELLULAR IMMUNITY IN EARLY POSTPARTUM PERIOD
Медицинская иммунология, 2021 The functioning of the secretory organs is closely related to the activity of the immune system. As is well known, this participation is manifested in the fact that at certain stages of activity, the lymphoid cells migrating to the organ can be involved ...
N. A. Panova, V. G. Skopichev
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Frontiers in Genetics, 2021 Altered microRNA expression patterns in bronchial brushings from people with versus without cystic fibrosis (CF) relate to functional changes and disease pathophysiology.
Paul J. McKiernan +4 more
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Memories of an X-chromosome [PDF]
Stem Cell Investigation, 2017 Peer ...
Lamas-Toranzo, I. +2 more
openaire +5 more sources
Assessment of external risk factors of hepatocellular cancer development and markers of genetic predisposition to its development in the ethnic group of yakut - men [PDF]
Терапевтический архив, 2020 Aim. To establish the main external and genetically determined risk factors for the development of hepatocellular cancer in the ethnic group of male Yakuts living in the Republic of Sakha (Yakutia) [RS (Y)] in the epidemiologically unfavorable conditions
N D Yushchuk +8 more
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Escape from X Chromosome Inactivation and the Female Predominance in Autoimmune Diseases
International Journal of Molecular Sciences, 2021 Women represent 80% of people affected by autoimmune diseases. Although, many studies have demonstrated a role for sex hormone receptor signaling, particularly estrogens, in the direct regulation of innate and adaptive components of the immune system ...
A. Youness +2 more
semanticscholar +1 more source