Results 21 to 30 of about 6,270,911 (362)
Condensin-Driven Remodeling of X-Chromosome Topology during Dosage Compensation
Nature, 2015 The three-dimensional organization of a genome plays a critical role in regulating gene expression, yet little is known about the machinery and mechanisms that determine higher-order chromosome structure.
Emily Crane +8 more
semanticscholar +1 more source
X chromosome and suicide [PDF]
Molecular Psychiatry, 2009 Suicide completion rates are significantly higher in males than females in most societies. Although gender differences in suicide rates have been partially explained by environmental and behavioral factors, it is possible that genetic factors, through differential expression between genders, may also help explain gender moderation of suicide risk. This
Hana Zouk +3 more
openaire +3 more sources
X chromosome inactivation during Drosophila spermatogenesis. [PDF]
PLoS Biology, 2007 Genes with male- and testis-enriched expression are under-represented on the Drosophila melanogaster X chromosome. There is also an excess of retrotransposed genes, many of which are expressed in testis, that have "escaped" the X chromosome and moved to ...
Winfried Hense +2 more
doaj +1 more source
Current Biology, 2008 I'd like to thank Catherine Montchamp-Moreau and Yun Tao for helpful comments on the manuscript.
openaire +3 more sources
The human inactive X chromosome modulates expression of the active X chromosome
Cell Genomics, 2023 Summary: The “inactive” X chromosome (Xi) has been assumed to have little impact, in trans, on the “active” X (Xa). To test this, we quantified Xi and Xa gene expression in individuals with one Xa and zero to three Xis.
Adrianna K. San Roman +21 more
doaj
Deciphering the Role of the Barr Body in Malignancy: An insight into head and neck cancer
Sultan Qaboos University Medical Journal, 2018 X chromosome inactivation is the epitome of epigenetic regulation and long non-coding ribonucleic acid function. The differentiation status of cells has been ascribed to X chromosome activity, with two active X chromosomes generally only observed in ...
Deepti Sharma +4 more
doaj +1 more source
Why Y chromosome is shorter and women live longer? [PDF]
Eur. Phys. J. B 65, 149-153 (2008), 2008 We have used the Penna ageing model to analyze how the differences in evolution of sex chromosomes depend on the strategy of reproduction. In panmictic populations, when females (XX) can freely choose the male partner (XY) for reproduction from the whole population, the Y chromosome accumulates defects and eventually the only information it brings is a
arxiv +1 more source
Telomere-to-telomere assembly of a complete human X chromosome
bioRxiv, 2019 After two decades of improvements, the current human reference genome (GRCh38) is the most accurate and complete vertebrate genome ever produced. However, no single chromosome has been finished end to end, and hundreds of unresolved gaps persist 1 , 2 ...
K. Miga +51 more
semanticscholar +1 more source
The probability to initiate X chromosome inactivation is determined by the X to autosomal ratio and X chromosome specific allelic properties. [PDF]
PLoS ONE, 2009 In female mammalian cells, random X chromosome inactivation (XCI) equalizes the dosage of X-encoded gene products to that in male cells. XCI is a stochastic process, in which each X chromosome has a probability to be inactivated.
Kim Monkhorst +10 more
doaj +1 more source
An excess of gene expression divergence on the X chromosome in Drosophila embryos; implications for the faster-X hypothesis [PDF]
PLoS Genetics (2012)8(12):e1003200, 2012 The X chromosome is present as a single copy in the heterogametic sex, and this hemizygosity is expected to drive unusual patterns of evolution on the X relative to the autosomes. For example, the hemizgosity of the X may lead to a lower chromosomal effective population size compared to the autosomes suggesting that the X might be more strongly ...
arxiv +1 more source