Differences of size and shape of active and inactive X-chromosome domains in human amniotic fluid cell nuclei [PDF]
, 1993 It is a widely held belief that the inactive X-chromosome (Xi) in female cell nuclei is strongly condensed as compared to the largely decondensed active X-chromosome (Xa).
Barr +39 more
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Current Biology, 2008 I'd like to thank Catherine Montchamp-Moreau and Yun Tao for helpful comments on the manuscript.
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The human inactive X chromosome modulates expression of the active X chromosome
Cell Genomics, 2023 Summary: The “inactive” X chromosome (Xi) has been assumed to have little impact, in trans, on the “active” X (Xa). To test this, we quantified Xi and Xa gene expression in individuals with one Xa and zero to three Xis.
Adrianna K. San Roman +21 more
doaj
Deciphering the Role of the Barr Body in Malignancy: An insight into head and neck cancer
Sultan Qaboos University Medical Journal, 2018 X chromosome inactivation is the epitome of epigenetic regulation and long non-coding ribonucleic acid function. The differentiation status of cells has been ascribed to X chromosome activity, with two active X chromosomes generally only observed in ...
Deepti Sharma +4 more
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Chromosomal in situ suppression hybridization of human gonosomes and autosomes and its use in clinical cytogenetics [PDF]
, 1990 DNA libraries from sorted human gonosomes were used selectively to stain the X and Y chromosomes in normal and aberrant cultured human cells by chromosomal in situ suppression (CISS-) hybridization.
Cremer, Thomas +5 more
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Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome
Nature Communications, 2016 It is unclear how often genetic mosaicism of chromosome X arises. Here, the authors examine women with cancer and cancer-free controls and show that X chromosome mosaicism occurs more frequently than on autosomes, especially on the inactive X chromosome,
Mitchell J. Machiela +175 more
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Monosomy for the X chromosome [PDF]
Chromosome Research, 2009 Dosage compensation serves to equalize X chromosome gene expression in mammalian males and females and involves extensive silencing of the 2nd X chromosome in females. If dosage compensation mechanisms completely suppressed the 2nd X chromosome, then actual physical loss of this "eXtra" chromosome should have few consequences.
Clara M. Cheng, Carolyn A. Bondy
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Amplification of the androgen receptor may not explain the development of androgen-independent prostate cancer [PDF]
, 2001 Objective To examine the role of androgen receptor (AR) gene amplification and aneusomy of the X chromosome in the development of antiandrogen-resistant prostate cancer.
Bartlett, J.M.S. +5 more
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The X chromosome and male infertility [PDF]
Human Genetics, 2019 AbstractThe X chromosome is a key player in germ cell development, as has been highlighted for males in previous studies revealing that the mammalian X chromosome is enriched in genes expressed in early spermatogenesis. In this review, we focus on the X chromosome’s unique biology as associated with human male infertility.
Vockel, Matthias +4 more
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Variation of autosomes and X chromosome STR in breast cancer and gynecological cancer tissues
Open Life Sciences, 2017 This study analyses 1000 cases of patients with breast cancer and 2000 cases of patients with gynecological cancer (1000 cases of malignant tumor, 1000 cases of benign tumors), where breast cancer and malignant tumor patients comprise the observation ...
Hou Youxiang +2 more
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