Results 21 to 30 of about 964,345 (336)

Partial dosage compensation in Strepsiptera, a sister group of beetles. [PDF]

, 2015
Sex chromosomes have evolved independently in many different taxa, and so have mechanisms to compensate for expression differences on sex chromosomes in males and females. Different clades have evolved vastly different ways to achieve dosage compensation,
Bachtrog, Doris, Mahajan, Shivani
core   +2 more sources

A case of acute lymphoblastic leukemia with additional chromosomes X and 5 associated with a Philadelphia chromosome in the bone marrow

Turkish Journal of Hematology, 2010
We report herein a very rare case of acute lymphoblastic leukemia having a chromosomal constitution of 48,XY,+X,+5,t(9;22)(q34;q11) in the bone marrow.
Burak Durmaz, Asude Alpman Durmaz, Emin Karaca, Güray Saydam, Özgür Çoğulu, Ferda Özkınay   +5 more
doaj   +3 more sources

Detectable chromosome X mosaicism in males is rarely tolerated in peripheral leukocytes

Scientific Reports, 2021
Age-related male Y and female X chromosome mosaicism is commonly observed in large population-based studies. To investigate the frequency of male X chromosome mosaicism, we scanned for deviations in chromosome X genotyping array intensity data in a ...
Weiyin Zhou, Shu-Hong Lin, Sairah M. Khan, Meredith Yeager, Stephen J. Chanock, Mitchell J. Machiela   +5 more
doaj   +1 more source

Large-Scale Analysis of X Inactivation Variations between Primed and Naïve Human Embryonic Stem Cells

Cells, 2022
X chromosome inactivation is a mammalian dosage compensation mechanism, where one of two X chromosomes is randomly inactivated in female cells. Previous studies have suggested that primed human embryonic stem cells (hESCs) maintain an eroded state of the
Roni Sarel-Gallily, Nissim Benvenisty
doaj   +1 more source

The Origin of a New Sex Chromosome by Introgression between Two Stickleback Fishes. [PDF]

, 2019
Introgression is increasingly recognized as a source of genetic diversity that fuels adaptation. Its role in the evolution of sex chromosomes, however, is not well known. Here, we confirm the hypothesis that the Y chromosome in the ninespine stickleback,
Abbott, Alexander, Anders, Bachtrog, Bachtrog, Bachtrog, Bronson, Browning, Carling, Carneiro, Charlesworth, Charlesworth, Choi, Cook, Corcoran, Coyne, Coyne, Danecek, DePristo, Edwards, Glazer, Green, Groves Dixon, Hagen, Irwin, Ishikawa, JanouŠek, Jay, Jombart, Jombart, Jun Kitano, Krueger, Langmead, Li, Li, Lindholm, Love, Luo, Mark Kirkpatrick, Martin, Martin, Martin, Meguro, Melissa Wilson Sayres, Muirhead, Natri, Neafsey, Nei, O’Neill, Payseur, Petit, Presgraves, Quinlan, Ravinet, Ross, Saetre, Sankararaman, Schwander, Sciuchetti, Smit, Stamatakis, Storchová, Stölting, Sun, Takahashi, Takahashi, Toews, Tosi, Toups, Tuttle, van Doorn, Vicoso, von Hippel, Wang, White, Yang, Yoshida, Yoshida, Úbeda   +78 more
core   +1 more source

Clinical and genetic characterisation of dystrophin-deficient muscular dystrophy in a family of Miniature Poodle dogs [PDF]

, 2018
Four full-sibling intact male Miniature Poodles were evaluated at 4–19 months of age. One was clinically normal and three were affected. All affected dogs were reluctant to exercise and had generalised muscle atrophy, a stiff gait and a markedly elevated
A Aartsma-Rus, A McKenna, Alberta de Stefani, Anita Shea, AP Monaco, AV Winnard, BA Valentine, BF Smith, BJ Cooper, C Le Guiner, C Pichavant, CA Collins, CA Jenkins, CA Wetterman, Carlos E. Ambrósio, CT Caskey, DE Cole, DJ VanBelzen, Elsa Beltrán, EM Hoogerwaard, EM Hoogerwaard, EP Hoffman, F Daoud, G Anil, G Bulfield, G. Diane Shelton, GD Shelton, GD Shelton, GD Shelton, GD Shelton, GL Walmsley, H Li, JA Goldstein, JL Carpenter, JN Kornegay, JN Kornegay, JR Mendell, JW McGreevy, K Bushby, K Nakamura, KJ Livak, KJ Nowak, Ling T. Guo, Lluís Sánchez, Louise M. Burmeister, LT Guo, Luisa De Risio, M Koenig, N Klymiuk, N Winand, NJ Olby, NJ Sharp, PP Nghiem, S Atencia-Fernandez, S Pouwels, S Rozen, SJ Schatzberg, SJ Schatzberg, T Larcher, U Francke, V Dubowitz, V Ricotti, W El Nemer, WI Baltzer   +63 more
core   +3 more sources

X chromosome control of meiotic chromosome synapsis in mouse inter-subspecific hybrids. [PDF]

PLoS Genetics, 2014
Hybrid sterility (HS) belongs to reproductive isolation barriers that safeguard the integrity of species in statu nascendi. Although hybrid sterility occurs almost universally among animal and plant species, most of our current knowledge comes from the ...
Tanmoy Bhattacharyya, Radka Reifova, Sona Gregorova, Petr Simecek, Vaclav Gergelits, Martin Mistrik, Iva Martincova, Jaroslav Pialek, Jiri Forejt   +8 more
doaj   +1 more source

On a break with the X: the role of repair of double-stranded DNA breaks in X-linked disease [PDF]

, 2012
The problem of managing free reactive DNA ends in eukaryotic cells has resulted in the development of a number of mechanisms in order to ensure that free ends are rendered non-reactive, or that the double-strand DNA breaks generating the free ends are ...
Cecceroni, Lucia, De Caris, Laura, Tummala, Hemanth   +2 more
core   +4 more sources

X chromosome and suicide [PDF]

Molecular Psychiatry, 2009
Suicide completion rates are significantly higher in males than females in most societies. Although gender differences in suicide rates have been partially explained by environmental and behavioral factors, it is possible that genetic factors, through differential expression between genders, may also help explain gender moderation of suicide risk. This
L M, Fiori, H, Zouk, C, Himmelman, G, Turecki   +3 more
openaire   +2 more sources

Dosage Sensing, Threshold Responses, and Epigenetic Memory: A Systems Biology Perspective on Random X‐Chromosome Inactivation

, 2020
X‐chromosome inactivation ensures dosage compensation between the sexes in mammals by randomly choosing one out of the two X chromosomes in females for inactivation.
Barr M. L., Comings D. E., Delbrück M., Rastan S., Rosspopoff O.   +4 more
core   +1 more source