Results 31 to 40 of about 6,270,911 (362)
The X chromosome and male infertility [PDF]
Human Genetics, 2019 AbstractThe X chromosome is a key player in germ cell development, as has been highlighted for males in previous studies revealing that the mammalian X chromosome is enriched in genes expressed in early spermatogenesis. In this review, we focus on the X chromosome’s unique biology as associated with human male infertility.
Vockel, Matthias +4 more
openaire +9 more sources
Variation of autosomes and X chromosome STR in breast cancer and gynecological cancer tissues
Open Life Sciences, 2017 This study analyses 1000 cases of patients with breast cancer and 2000 cases of patients with gynecological cancer (1000 cases of malignant tumor, 1000 cases of benign tumors), where breast cancer and malignant tumor patients comprise the observation ...
Hou Youxiang +2 more
doaj +1 more source
Primary extranodal diffuse large B‐cell lymphoma: Molecular features, treatment, and prognosis
Aging and Cancer, Volume 3, Issue 3-4, Page 133-146, September-December 2022., 2022 One‐third of DLBCL arises from extranodal organs and is challenging to manage. Molecular features are critical to elucidate the differences in clinical features, predict the disease prognosis, and improve effective targeted therapeutic strategies. Abstract Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin's lymphoma and ...
Si‐Yuan Chen +3 more
wiley +1 more source
Cells, 2022 X chromosome inactivation is a mammalian dosage compensation mechanism, where one of two X chromosomes is randomly inactivated in female cells. Previous studies have suggested that primed human embryonic stem cells (hESCs) maintain an eroded state of the
Roni Sarel-Gallily, Nissim Benvenisty
doaj +1 more source
A Symmetry Breaking Model for X Chromosome Inactivation [PDF]
Phys. Rev. Lett. 98, 108104 (2007), 2008 In mammals, dosage compensation of X linked genes in female cells is achieved by inactivation of one of their two X chromosomes which is randomly chosen. The earliest steps in X-inactivation (XCI), namely the mechanism whereby cells count their X chromosomes and choose between two equivalent X, remain mysterious. Starting from the recent discovery of X
arxiv +1 more source
3D genome reconstruction from partially phased Hi-C data [PDF]
Bulletin of Mathematical Biology 86, 33 (2024), 2023 The 3-dimensional (3D) structure of the genome is of significant importance for many cellular processes. In this paper, we study the problem of reconstructing the 3D structure of chromosomes from Hi-C data of diploid organisms, which poses additional challenges compared to the better-studied haploid setting.
arxiv +1 more source
Detectable chromosome X mosaicism in males is rarely tolerated in peripheral leukocytes
Scientific Reports, 2021 Age-related male Y and female X chromosome mosaicism is commonly observed in large population-based studies. To investigate the frequency of male X chromosome mosaicism, we scanned for deviations in chromosome X genotyping array intensity data in a ...
Weiyin Zhou +5 more
doaj +1 more source
X chromosome-linked muscular dystrophy (mdx) in the mouse.
Proceedings of the National Academy of Sciences of the United States of America, 1984 An X chromosome-linked mouse mutant (gene symbol, mdx) has been found that has elevated plasma levels of muscle creatine kinase and pyruvate kinase and exhibits histological lesions characteristic of muscular dystrophy.
G. Bulfield +3 more
semanticscholar +1 more source
X chromosome control of meiotic chromosome synapsis in mouse inter-subspecific hybrids. [PDF]
PLoS Genetics, 2014 Hybrid sterility (HS) belongs to reproductive isolation barriers that safeguard the integrity of species in statu nascendi. Although hybrid sterility occurs almost universally among animal and plant species, most of our current knowledge comes from the ...
Tanmoy Bhattacharyya +8 more
doaj +1 more source
Turkish Journal of Hematology, 2010 We report herein a very rare case of acute lymphoblastic leukemia having a chromosomal constitution of 48,XY,+X,+5,t(9;22)(q34;q11) in the bone marrow.
Burak Durmaz +5 more
doaj +3 more sources