Results 11 to 20 of about 196,851 (322)

X-chromosome inactivation and escape [PDF]

Journal of Genetics, 2015
X-chromosome inactivation, which was discovered by Mary Lyon in 1961 results in random silencing of one X chromosome in female mammals. This review is dedicated to Mary Lyon, who passed away last year. She predicted many of the features of X inactivation, for e.g., the existence of an X inactivation center, the role of L1 elements in spreading of ...
C. Disteche, J. B. Berletch
semanticscholar   +3 more sources

X chromosome inactivation across primary human tissues is mostly complete, with significant implications for genetic and clinical studies. [PDF]

BMC Genomics
Shriner D, Doumatey AP, Lei L, Gouveia MH, Meeks KAC, Heuston EF, Zhou J, Adeyemo AA, Rotimi CN.   +8 more
europepmc   +2 more sources

Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of pDCs in systemic sclerosis. [PDF]

J Exp Med
Du Y, Faz-Lopez B, Ah Kioon MD, Cenac C, Pierides M, Lakin KS, Spiera RF, Chaumeil J, Truchetet ME, Gordon JK, Guéry JC, Barrat FJ.   +11 more
europepmc   +3 more sources

Inexpensive protocol for single-cell X-chromosome inactivation analysis: Xist expression and H3K27me3 staining [PDF]

Письма в Вавиловский журнал генетики и селекции, 2022
The X-chromosome status is an important marker of mammalian cell embryonic differentiation. Both female X-chromosomes are transcriptionally active (Xa) at the blastocyst stage, then one of the X-chromosomes undergoes random inactivation (Xi).
Pristyazhnyuk I.E., Meshcheryakov N.I., Menzorov A.G   +2 more
doaj   +1 more source

Escape from X Chromosome Inactivation and the Female Predominance in Autoimmune Diseases

International Journal of Molecular Sciences, 2021
Women represent 80% of people affected by autoimmune diseases. Although, many studies have demonstrated a role for sex hormone receptor signaling, particularly estrogens, in the direct regulation of innate and adaptive components of the immune system ...
A. Youness, Charles-Henry Miquel, J. Guéry   +2 more
semanticscholar   +1 more source

Elastic dosage compensation by X-chromosome upregulation

Nature Communications, 2022
The concerted dynamics of X-chromosome upregulation and X-chromosome inactivation, which collectively balance X-chromosome expression, are not well understood.
Antonio Lentini, Huaitao Cheng, J. C. Noble, Natali Papanicolaou, Christos Coucoravas, Nathanael Andrews, Qiaolin Deng, Martin Enge, Björn Reinius   +8 more
doaj   +1 more source

Large-Scale Analysis of X Inactivation Variations between Primed and Naïve Human Embryonic Stem Cells

Cells, 2022
X chromosome inactivation is a mammalian dosage compensation mechanism, where one of two X chromosomes is randomly inactivated in female cells. Previous studies have suggested that primed human embryonic stem cells (hESCs) maintain an eroded state of the
Roni Sarel-Gallily, Nissim Benvenisty
doaj   +1 more source

A female patient with Dent disease due to skewed X-chromosome inactivation. [PDF]

Clin Kidney J
D'Ambrosio V, Wan ER, Siew K, Hayes W, Walsh SB.   +4 more
europepmc   +3 more sources

Evidence of influence of genomic DNA sequence on human X chromosome inactivation. [PDF]

PLoS Computational Biology, 2006
A significant number of human X-linked genes escape X chromosome inactivation and are thus expressed from both the active and inactive X chromosomes. The basis for escape from inactivation and the potential role of the X chromosome primary DNA sequence ...
Zhong Wang, Huntington F Willard, Sayan Mukherjee, Terrence S Furey   +3 more
doaj   +1 more source

Large-scale population study of human cell lines indicates that dosage compensation is virtually complete. [PDF]

PLoS Genetics, 2008
X chromosome inactivation in female mammals results in dosage compensation of X-linked gene products between the sexes. In humans there is evidence that a substantial proportion of genes escape from silencing.
Colette M Johnston, Frances L Lovell, Daniel A Leongamornlert, Barbara E Stranger, Emmanouil T Dermitzakis, Mark T Ross   +5 more
doaj   +1 more source