Results 31 to 40 of about 317,261 (329)
X chromosomes alternate between two states prior to random X-inactivation. [PDF]
PLoS Biology, 2006 Early in the development of female mammals, one of the two X chromosomes is silenced in half of cells and the other X chromosome is silenced in the remaining half. The basis of this apparent randomness is not understood.
Susanna Mlynarczyk-Evans +6 more
doaj +1 more source
The X chromosome and sex-specific effects in infectious disease susceptibility
Human Genomics, 2019 The X chromosome and X-linked variants have largely been ignored in genome-wide and candidate association studies of infectious diseases due to the complexity of statistical analysis of the X chromosome.
Haiko Schurz +5 more
doaj +1 more source
X Chromosome Inactivation during Grasshopper Spermatogenesis [PDF]
Genes, 2021 Regulation of transcriptional activity during meiosis depends on the interrelated processes of recombination and synapsis. In eutherian mammal spermatocytes, transcription levels change during prophase-I, being low at the onset of meiosis but highly increased from pachytene up to the end of diplotene. However, X and Y chromosomes, which usually present
Alberto Viera +5 more
openaire +3 more sources
The X-inactivation trans-activator Rnf12 is negatively regulated by pluripotency factors in embryonic stem cells [PDF]
, 2011 X-inactivation, the molecular mechanism enabling dosage compensation in mammals, is tightly controlled during mouse early embryogenesis. In the morula, X-inactivation is imprinted with exclusive silencing of the paternally inherited X-chromosome.
Pablo Navarro +3 more
core +2 more sources
X Inactivation Lessons from Differentiating Mouse Embryonic Stem Cells [PDF]
, 2015 X chromosome inactivation (XCI) is the dosage compensation mechanism that evolved in female mammals to correct the genetic imbalance of X-linked genes between sexes.
Andrea Cerase, Greta Pintacuda
core +1 more source
Rlim/Rnf12, Rex1, and X Chromosome Inactivation
Frontiers in Cell and Developmental Biology, 2019 RLIM/Rnf12 is an E3 ubiquitin ligase that has originally been identified as a transcriptional cofactor associated with LIM domain transcription factors.
Feng Wang, Ingolf Bach
doaj +1 more source
Nucleus, 2021 Mammals use X chromosome inactivation to compensate for the sex difference in numbers of X chromosomes. A relatively unexplored question is how the active X is protected from inactivation by its own XIST gene, the long non-coding RNA, which initiates ...
Barbara R. Migeon
doaj +1 more source
Single-cell analysis reveals X upregulation is not global in pre-gastrulation embryos
iScience, 2022 Summary: In mammals, transcriptional inactivation of one X chromosome in female compensates for the dosage of X-linked gene expression between the sexes.
Hemant Chandru Naik +4 more
doaj +1 more source
, 2020 X‐chromosome inactivation ensures dosage compensation between the sexes in mammals by randomly choosing one out of the two X chromosomes in females for inactivation.
Barr M. L. +4 more
core +1 more source
Partial dosage compensation in Strepsiptera, a sister group of beetles. [PDF]
, 2015 Sex chromosomes have evolved independently in many different taxa, and so have mechanisms to compensate for expression differences on sex chromosomes in males and females. Different clades have evolved vastly different ways to achieve dosage compensation,
Bachtrog, Doris, Mahajan, Shivani
core +2 more sources