Results 11 to 20 of about 317,261 (329)

The Implication of Early Chromatin Changes in X Chromosome Inactivation

Cell, 2019
Summary During development, the precise relationships between transcription and chromatin modifications often remain unclear. We use the X chromosome inactivation (XCI) paradigm to explore the implication of chromatin changes in gene silencing.
J. J. Żylicz, Aurélie Bousard, Kristina Žumer, François Dossin, Eusra Mohammad, S. T. da Rocha, B. Schwalb, L. Syx, F. Dingli, D. Loew, P. Cramer, E. Heard   +11 more
semanticscholar   +3 more sources

Human Naive Pluripotent Stem Cells Model X Chromosome Dampening and X Inactivation [PDF]

Cell Stem Cell, 2017
Naive human embryonic stem cells (hESCs) can be derived from primed hESCs or directly from blastocysts, but their X chromosome state has remained unresolved.
Bonora, Giancarlo, Chronis, Constantinos, Clark, Amander T., Jaenisch, Rudolf, Kim, Rachel, Kuoy, Edward, Langerman, Justin, Plath, Kathrin, Sabri, Shan, Sahakyan, Anna, Theunissen, Thorold W.   +10 more
core   +3 more sources

Global Characterization of X Chromosome Inactivation in Human Pluripotent Stem Cells

Cell Reports, 2019
Summary: Dosage compensation of sex-chromosome gene expression between male and female mammals is achieved via X chromosome inactivation (XCI) by employing epigenetic modifications to randomly silence one X chromosome during early embryogenesis.
Shiran Bar, Lev Roz Seaton, Uri Weissbein, Talia Eldar-Geva, Nissim Benvenisty   +4 more
doaj   +2 more sources

Identification of skewed X chromosome inactivation using exome and transcriptome sequencing in patients with suspected rare genetic disease [PDF]

BMC Genomics
Background X-chromosome inactivation (XCI) is an epigenetic process that occurs during early development in mammalian females by randomly silencing one of two copies of the X chromosome in each cell.
Numrah Fadra, Laura E Schultz-Rogers, Pritha Chanana, Margot A Cousin, Erica L Macke, Alejandro Ferrer, Filippo Pinto e Vairo, Rory J Olson, Gavin R Oliver, Lindsay A Mulvihill, Garrett Jenkinson, Eric W Klee   +11 more
doaj   +2 more sources

X chromosome inactivation unravelled [PDF]

Nature Reviews Genetics, 2015
openaire   +3 more sources

Escape from X Chromosome Inactivation and the Female Predominance in Autoimmune Diseases

International Journal of Molecular Sciences, 2021
Women represent 80% of people affected by autoimmune diseases. Although, many studies have demonstrated a role for sex hormone receptor signaling, particularly estrogens, in the direct regulation of innate and adaptive components of the immune system ...
A. Youness, Charles-Henry Miquel, J. Guéry   +2 more
semanticscholar   +1 more source

Inexpensive protocol for single-cell X-chromosome inactivation analysis: Xist expression and H3K27me3 staining [PDF]

Письма в Вавиловский журнал генетики и селекции, 2022
The X-chromosome status is an important marker of mammalian cell embryonic differentiation. Both female X-chromosomes are transcriptionally active (Xa) at the blastocyst stage, then one of the X-chromosomes undergoes random inactivation (Xi).
Pristyazhnyuk I.E., Meshcheryakov N.I., Menzorov A.G   +2 more
doaj   +1 more source

Elastic dosage compensation by X-chromosome upregulation

Nature Communications, 2022
The concerted dynamics of X-chromosome upregulation and X-chromosome inactivation, which collectively balance X-chromosome expression, are not well understood.
Antonio Lentini, Huaitao Cheng, J. C. Noble, Natali Papanicolaou, Christos Coucoravas, Nathanael Andrews, Qiaolin Deng, Martin Enge, Björn Reinius   +8 more
doaj   +1 more source

Mechanisms of Choice in X-Chromosome Inactivation

Cells, 2022
Early in development, placental and marsupial mammals harbouring at least two X chromosomes per nucleus are faced with a choice that affects the rest of their lives: which of those X chromosomes to transcriptionally inactivate.
G. Furlan, Rafael Galupa
semanticscholar   +1 more source

Large-Scale Analysis of X Inactivation Variations between Primed and Naïve Human Embryonic Stem Cells

Cells, 2022
X chromosome inactivation is a mammalian dosage compensation mechanism, where one of two X chromosomes is randomly inactivated in female cells. Previous studies have suggested that primed human embryonic stem cells (hESCs) maintain an eroded state of the
Roni Sarel-Gallily, Nissim Benvenisty
doaj   +1 more source