Results 11 to 20 of about 92,054 (252)
Inexpensive protocol for single-cell X-chromosome inactivation analysis: Xist expression and H3K27me3 staining [PDF]
Письма в Вавиловский журнал генетики и селекции, 2022 The X-chromosome status is an important marker of mammalian cell embryonic differentiation. Both female X-chromosomes are transcriptionally active (Xa) at the blastocyst stage, then one of the X-chromosomes undergoes random inactivation (Xi).
Pristyazhnyuk I.E. +2 more
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Elastic dosage compensation by X-chromosome upregulation
Nature Communications, 2022 The concerted dynamics of X-chromosome upregulation and X-chromosome inactivation, which collectively balance X-chromosome expression, are not well understood.
Antonio Lentini +8 more
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Cells, 2022 X chromosome inactivation is a mammalian dosage compensation mechanism, where one of two X chromosomes is randomly inactivated in female cells. Previous studies have suggested that primed human embryonic stem cells (hESCs) maintain an eroded state of the
Roni Sarel-Gallily, Nissim Benvenisty
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Large-scale population study of human cell lines indicates that dosage compensation is virtually complete. [PDF]
PLoS Genetics, 2008 X chromosome inactivation in female mammals results in dosage compensation of X-linked gene products between the sexes. In humans there is evidence that a substantial proportion of genes escape from silencing.
Colette M Johnston +5 more
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Characterisation of inactivation domains and evolutionary strata in human X chromosome through Markov segmentation. [PDF]
PLoS ONE, 2009 Markov segmentation is a method of identifying compositionally different subsequences in a given symbolic sequence. We have applied this technique to the DNA sequence of the human X chromosome to analyze its compositional structure.
Ashwin Kelkar +3 more
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X-Chromosome Inactivation [PDF]
Current Biology, 1994 In female mammals, all X chromosomes except one are transcriptionally inactivated early in embryonic development. This is known as X-chromosome inactivation and is a form of dosage compensation, giving equal dosage of the products of X-linked genes in males and females. The mechanism is of considerable interest as an example of differential behavior of
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PLoS ONE, 2014 In rodent female mammals, there are two forms of X-inactivation - imprinted and random which take place in extraembryonic and embryonic tissues, respectively.
Evgeniya A Vaskova +7 more
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X chromosomes alternate between two states prior to random X-inactivation. [PDF]
PLoS Biology, 2006 Early in the development of female mammals, one of the two X chromosomes is silenced in half of cells and the other X chromosome is silenced in the remaining half. The basis of this apparent randomness is not understood.
Susanna Mlynarczyk-Evans +6 more
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The X chromosome and sex-specific effects in infectious disease susceptibility
Human Genomics, 2019 The X chromosome and X-linked variants have largely been ignored in genome-wide and candidate association studies of infectious diseases due to the complexity of statistical analysis of the X chromosome.
Haiko Schurz +5 more
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X‐chromosome inactivation in development and cancer [PDF]
FEBS Letters, 2014 X‐chromosome inactivation represents an epigenetics paradigm and a powerful model system of facultative heterochromatin formation triggered by a non‐coding RNA, Xist, during development. Once established, the inactive state of the Xi is highly stable in somatic cells, thanks to a combination of chromatin associated proteins, DNA methylation and nuclear
Chaligné, Ronan, Heard, Edith
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