Results 21 to 30 of about 92,054 (252)
Skewed X-Chromosome Inactivation in Scleroderma [PDF]
Clinical Reviews in Allergy & Immunology, 2007 Scleroderma is a female-prevalent autoimmune disease of unclear etiology. Two fundamental gender differences, skewed X-chromosome inactivation (XCI) and pregnancy-related microchimerism, have been implicated in scleroderma. We investigated the XCI patterns of female scleroderma patients and the parental origin of the inactive X chromosome in those ...
Uz, E. +6 more
openaire +5 more sources
Single-cell analysis reveals X upregulation is not global in pre-gastrulation embryos
iScience, 2022 Summary: In mammals, transcriptional inactivation of one X chromosome in female compensates for the dosage of X-linked gene expression between the sexes.
Hemant Chandru Naik +4 more
doaj +1 more source
Rlim/Rnf12, Rex1, and X Chromosome Inactivation
Frontiers in Cell and Developmental Biology, 2019 RLIM/Rnf12 is an E3 ubiquitin ligase that has originally been identified as a transcriptional cofactor associated with LIM domain transcription factors.
Feng Wang, Ingolf Bach
doaj +1 more source
Nucleus, 2021 Mammals use X chromosome inactivation to compensate for the sex difference in numbers of X chromosomes. A relatively unexplored question is how the active X is protected from inactivation by its own XIST gene, the long non-coding RNA, which initiates ...
Barbara R. Migeon
doaj +1 more source
A scaffold for X chromosome inactivation
Human Genetics, 2011 X chromosome inactivation (XCI), the silencing of one of the two X chromosomes in XX female cells, equalises the dosage of X-linked genes relative to XY males. The process is mediated by the non-coding RNA X inactive specific transcript (Xist) that binds in cis and propagates along the inactive X chromosome elect, triggering chromosome-wide silencing ...
Tattermusch, A, Brockdorff, N
openaire +4 more sources
X-Chromosome Inactivation and Related Diseases
Genetics Research, 2022 X-chromosome inactivation (XCI) is the form of dosage compensation in mammalian female cells to balance X-linked gene expression levels of the two sexes.
Zhuo Sun, Jinbo Fan, Yang Wang
doaj +1 more source
Clinical expression of Menkes disease in females with normal karyotype
Orphanet Journal of Rare Diseases, 2012 Background Menkes Disease (MD) is a rare X-linked recessive fatal neurodegenerative disorder caused by mutations in the ATP7A gene, and most patients are males.
Møller Lisbeth +13 more
doaj +1 more source
Conversion of random X-inactivation to imprinted X-inactivation by maternal PRC2
eLife, 2019 Imprinted X-inactivation silences genes exclusively on the paternally-inherited X-chromosome and is a paradigm of transgenerational epigenetic inheritance in mammals. Here, we test the role of maternal vs.
Clair Harris +7 more
doaj +1 more source
Epigenetics & Chromatin, 2008 Background X chromosome inactivation is the mechanism used in mammals to achieve dosage compensation of X-linked genes in XX females relative to XY males. Chromosome silencing is triggered in cis by expression of the non-coding RNA Xist. As such, correct
Nesterova Tatyana B +10 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source