Results 21 to 30 of about 317,261 (329)

Evidence of influence of genomic DNA sequence on human X chromosome inactivation. [PDF]

PLoS Computational Biology, 2006
A significant number of human X-linked genes escape X chromosome inactivation and are thus expressed from both the active and inactive X chromosomes. The basis for escape from inactivation and the potential role of the X chromosome primary DNA sequence ...
Zhong Wang, Huntington F Willard, Sayan Mukherjee, Terrence S Furey   +3 more
doaj   +1 more source

The Molecular and Nuclear Dynamics of X-Chromosome Inactivation.

Cold Spring Harbor Perspectives in Biology, 2021
In female eutherian mammals, dosage compensation of X-linked gene expression is achieved during development through transcriptional silencing of one of the two X chromosomes.
François Dossin, E. Heard
semanticscholar   +1 more source

Large-scale population study of human cell lines indicates that dosage compensation is virtually complete. [PDF]

PLoS Genetics, 2008
X chromosome inactivation in female mammals results in dosage compensation of X-linked gene products between the sexes. In humans there is evidence that a substantial proportion of genes escape from silencing.
Colette M Johnston, Frances L Lovell, Daniel A Leongamornlert, Barbara E Stranger, Emmanouil T Dermitzakis, Mark T Ross   +5 more
doaj   +1 more source

X chromosome inactivation in human development

Development, 2020
X chromosome inactivation (XCI) is a key developmental process taking place in female mammals to compensate for the imbalance in the dosage of X-chromosomal genes between sexes.
C. Patrat, Jean-François Ouimette, C. Rougeulle   +2 more
semanticscholar   +1 more source

Characterisation of inactivation domains and evolutionary strata in human X chromosome through Markov segmentation. [PDF]

PLoS ONE, 2009
Markov segmentation is a method of identifying compositionally different subsequences in a given symbolic sequence. We have applied this technique to the DNA sequence of the human X chromosome to analyze its compositional structure.
Ashwin Kelkar, Vivek Thakur, Ramakrishna Ramaswamy, Deepti Deobagkar   +3 more
doaj   +1 more source

Landscape of X chromosome inactivation across human tissues

Nature, 2016
X chromosome inactivation (XCI) silences transcription from one of the two X chromosomes in female mammalian cells to balance expression dosage between XX females and XY males. XCI is, however, incomplete in humans: up to one-third of X-chromosomal genes
T. Tukiainen, A. Villani, Angela Yen, M. Rivas, Jamie L. Marshall, R. Satija, Matthew Aguirre, L. Gauthier, M. Fleharty, Andrew W. Kirby, Beryl B. Cummings, S. Castel, K. Karczewski, F. Aguet, Andrea Byrnes, T. Lappalainen, A. Regev, K. Ardlie, N. Hacohen, D. MacArthur   +19 more
semanticscholar   +1 more source

X-Chromosome Inactivation [PDF]

Current Biology, 1994
In female mammals, all X chromosomes except one are transcriptionally inactivated early in embryonic development. This is known as X-chromosome inactivation and is a form of dosage compensation, giving equal dosage of the products of X-linked genes in males and females. The mechanism is of considerable interest as an example of differential behavior of
openaire   +2 more sources

Dynamics of the two heterochromatin types during imprinted X chromosome inactivation in vole Microtus levis.

PLoS ONE, 2014
In rodent female mammals, there are two forms of X-inactivation - imprinted and random which take place in extraembryonic and embryonic tissues, respectively.
Evgeniya A Vaskova, Elena V Dementyeva, Alexander I Shevchenko, Sophia V Pavlova, Elena V Grigor'eva, Antonina I Zhelezova, John L Vandeberg, Suren M Zakian   +7 more
doaj   +1 more source

Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development

Nature, 2011
I. Okamoto, C. Patrat, D. Thépot, N. Peynot, P. Fauque, N. Daniel, Patricia Diabangouaya, J. Wolf, J. Renard, V. Duranthon, E. Heard   +10 more
semanticscholar   +3 more sources

Activity map of the tammar X chromosome shows that marsupial X inactivation is incomplete and escape is stochastic [PDF]

, 2016
BACKGROUND: X chromosome inactivation is a spectacular example of epigenetic silencing. In order to deduce how this complex system evolved, we examined X inactivation in a model marsupial, the tammar wallaby (Macropus eugenii).
Al Nadaf, Shafagh, Deakin, Janine E., Graves, Jennifer A., Jordan, Kristen S., Koina, Edda, Waters, Paul D.   +5 more
core   +1 more source