Results 21 to 30 of about 196,851 (322)
The Molecular and Nuclear Dynamics of X-Chromosome Inactivation.
Cold Spring Harbor Perspectives in Biology, 2021 In female eutherian mammals, dosage compensation of X-linked gene expression is achieved during development through transcriptional silencing of one of the two X chromosomes.
François Dossin, E. Heard
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Characterisation of inactivation domains and evolutionary strata in human X chromosome through Markov segmentation. [PDF]
PLoS ONE, 2009 Markov segmentation is a method of identifying compositionally different subsequences in a given symbolic sequence. We have applied this technique to the DNA sequence of the human X chromosome to analyze its compositional structure.
Ashwin Kelkar +3 more
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X chromosomes alternate between two states prior to random X-inactivation. [PDF]
PLoS Biology, 2006 Early in the development of female mammals, one of the two X chromosomes is silenced in half of cells and the other X chromosome is silenced in the remaining half. The basis of this apparent randomness is not understood.
Susanna Mlynarczyk-Evans +6 more
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Landscape of X chromosome inactivation across human tissues
Nature, 2016 X chromosome inactivation (XCI) silences transcription from one of the two X chromosomes in female mammalian cells to balance expression dosage between XX females and XY males. XCI is, however, incomplete in humans: up to one-third of X-chromosomal genes
T. Tukiainen +19 more
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X-Chromosome Inactivation [PDF]
Current Biology, 1994 In female mammals, all X chromosomes except one are transcriptionally inactivated early in embryonic development. This is known as X-chromosome inactivation and is a form of dosage compensation, giving equal dosage of the products of X-linked genes in males and females. The mechanism is of considerable interest as an example of differential behavior of
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PLoS ONE, 2014 In rodent female mammals, there are two forms of X-inactivation - imprinted and random which take place in extraembryonic and embryonic tissues, respectively.
Evgeniya A Vaskova +7 more
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X chromosome inactivation in human development
Development, 2020 X chromosome inactivation (XCI) is a key developmental process taking place in female mammals to compensate for the imbalance in the dosage of X-chromosomal genes between sexes.
C. Patrat +2 more
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The X chromosome and sex-specific effects in infectious disease susceptibility
Human Genomics, 2019 The X chromosome and X-linked variants have largely been ignored in genome-wide and candidate association studies of infectious diseases due to the complexity of statistical analysis of the X chromosome.
Haiko Schurz +5 more
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X Chromosome Inactivation during Grasshopper Spermatogenesis [PDF]
Genes, 2021 Regulation of transcriptional activity during meiosis depends on the interrelated processes of recombination and synapsis. In eutherian mammal spermatocytes, transcription levels change during prophase-I, being low at the onset of meiosis but highly increased from pachytene up to the end of diplotene. However, X and Y chromosomes, which usually present
Alberto Viera +5 more
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Cell Reports, 2019 Summary: Neural tube defects (NTDs) are common birth defects in humans and show an unexplained female bias. Female mice lacking the tumor suppressor p53 display NTDs with incomplete penetrance. We found that the combined loss of pro-apoptotic BIM and p53
Alex R.D. Delbridge +21 more
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