Nucleus, 2021 Mammals use X chromosome inactivation to compensate for the sex difference in numbers of X chromosomes. A relatively unexplored question is how the active X is protected from inactivation by its own XIST gene, the long non-coding RNA, which initiates ...
Barbara R. Migeon
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Single-cell analysis reveals X upregulation is not global in pre-gastrulation embryos
iScience, 2022 Summary: In mammals, transcriptional inactivation of one X chromosome in female compensates for the dosage of X-linked gene expression between the sexes.
Hemant Chandru Naik +4 more
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Rlim/Rnf12, Rex1, and X Chromosome Inactivation
Frontiers in Cell and Developmental Biology, 2019 RLIM/Rnf12 is an E3 ubiquitin ligase that has originally been identified as a transcriptional cofactor associated with LIM domain transcription factors.
Feng Wang, Ingolf Bach
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X-Chromosome Inactivation: A Crossroads Between Chromosome Architecture and Gene Regulation.
Annual Review of Genetics, 2018 In somatic nuclei of female therian mammals, the two X chromosomes display very different chromatin states: One X is typically euchromatic and transcriptionally active, and the other is mostly silent and forms a cytologically detectable heterochromatic ...
Rafael Galupa, E. Heard
semanticscholar +1 more source
Genes that escape from X‐chromosome inactivation: Potential contributors to Klinefelter syndrome
American Journal of Medical Genetics. Part C, Seminars in Medical Genetics, 2020 One of the two X chromosomes in females is epigenetically inactivated, thereby compensating for the dosage difference in X‐linked genes between XX females and XY males.
Maria Jose Navarro-Cobos +2 more
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Escape from X chromosome inactivation and female bias of autoimmune diseases
Molecular Medicine, 2020 Generally, autoimmune diseases are more prevalent in females than males. Various predisposing factors, including female sex hormones, X chromosome genes, and the microbiome have been implicated in the female bias of autoimmune diseases.
M. Mousavi, M. Mahmoudi, S. Ghotloo
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Systematic allelic analysis defines the interplay of key pathways in X chromosome inactivation
Nature Communications, 2018 Xist RNA, the master regulator of X chromosome inactivation, acts in cis to induce chromosome-wide silencing. Whilst recent studies have defined candidate silencing factors, their relative contribution to repressing different genes, and their ...
T. Nesterova +14 more
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Clinical expression of Menkes disease in females with normal karyotype
Orphanet Journal of Rare Diseases, 2012 Background Menkes Disease (MD) is a rare X-linked recessive fatal neurodegenerative disorder caused by mutations in the ATP7A gene, and most patients are males.
Møller Lisbeth +13 more
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Conversion of random X-inactivation to imprinted X-inactivation by maternal PRC2
eLife, 2019 Imprinted X-inactivation silences genes exclusively on the paternally-inherited X-chromosome and is a paradigm of transgenerational epigenetic inheritance in mammals. Here, we test the role of maternal vs.
Clair Harris +7 more
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Unraveling the role of Xist in X chromosome inactivation: insights from rabbit model and deletion analysis of exons and repeat A. [PDF]
Cell Mol Life SciLiang M, Zhang L, Lai L, Li Z.
europepmc +3 more sources