Results 101 to 110 of about 107,799 (290)

Synthesis, physical and chemical properties of 7-methylxanthine derivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
It is known that 8-aminosubstituted N-methylated xanthines are dipeptidyl peptidase-4 antagonists, ligands for 5-hydroxytryptamine receptors and exert diverse biological effects.
M. I. Romanenko, O. P. Dolhikh, D. H. Ivanchenko, K. V. Aleksandrova   +3 more
doaj   +1 more source

Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase‐catalyzed xanthine and 6‐mercaptopurine oxidation

Journal of the Science of Food and Agriculture, Volume 105, Issue 5, Page 2765-2776, 30 March 2025.
Abstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Tímea Bencsik, Orsolya Balázs, Róbert G Vida, Balázs Z Zsidó, Csaba Hetényi, Kateřina Valentová, Miklós Poór   +6 more
wiley   +1 more source

Simultaneous Electrochemical Determination of Uric Acid, Xanthine, and Hypoxanthine Using AgNPs/MIL-101(Cr) Modified Electrode

ECS Sensors Plus
This paper presents silver nanoparticles supported by the Matérial Institute Lavoisier-101 (AgNPs/MIL-101(Cr)) for electrochemical determination of uric acid (URA), xanthine (XAT), and hypoxanthine (HPX).
Nguyen Quang Man, Nguyen Ngoc Nghia, Vo Thi Khanh Ly, Nguyen Duc Vu Quyen, Le Thi Hoa, Ho Van Minh Hai, Le Van Thanh Son, Le Thi Hong Phong, Nguyen Dinh Luyen, Nguyen Chi Bao, Dinh Quang Khieu   +10 more
doaj   +1 more source

The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching [PDF]

, 2013
Significance: a mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow - 'hypoxic vasodilation' - occur in an ...
Alex Dyson, Audibert G, Berne RM, Blitzer ML, Boutilier RG, Brown IP, Devlin C, Furukawa K, Hall JE, Heyes MP, Jekabsone A, Lehninger A, Leone AM, Louis CA, Martin Feelisch, Mervyn Singer, Michele Umbrello, Modin A, Munk VC, Pohl U, Rengasamy A, Rengasamy A, Vallance P, Whorton AR   +23 more
core   +1 more source

Assessment of purine catabolism and morbidity in miners depending on their work experience

Russian Open Medical Journal
Objective — The role of end products of purine metabolism as predictors of the development of pathological changes and diseases caused by the impact of dust on the human body in a professional environment vs.
Diana M. Shaukhat, Lyazat K. Ibrayeva, Dina Kh. Rybalkina, Irina V. Bacheva, Igor V. Bukhtiyarov, Aigul U. Amanbekova, Tleуuzhan O. Abugalieva   +6 more
doaj   +1 more source

Synthesis of 1,2,3,4‐Tetrahydroisoquinoline‐3‐Carboxylic Acid‐Embedded Decapeptides: In Silico Studies and In Vitro Evaluation Against Breast Cancer

ChemistryOpen, EarlyView.
Synthesized decapeptides were designed and validated by in silico studies. They have significantly exhibited anticancer potential against breast cancer and MCF‐7 cell line. The above illustration specifies the synthetic pathway, biological screening, and the mode of action of the peptide in blocking the pathways responsible for the growth of cancer ...
Sunil Tivari, Naurin Lalani, Pritam Bagwe, Prashant Chandole, Ramesh Pawar, Enrique Delgado‐Alvarado, Abdallah Othman Ghnaim, Yashwantsinh Jadeja   +7 more
wiley   +1 more source

Synthesis and physical-chemical properties of 8-benzylidenhydrazino-1-(4-fluorobenzyl)theobromine derivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2014
The aim of the work is thesynthesis and research of physical and chemical properties of earlier undescribed 1,8-disubstituted of theobromine, which are potential biologically active compounds.
D. G. Ivanchenko, M. I. Romanenko, E. V. Alexandrova, A. S. Korjova   +3 more
doaj   +1 more source

Uric Acid in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Portal Hypertension &Cirrhosis, EarlyView.
MASLD is the most prevalent chronic liver disease worldwide, yet effective pharmacological treatments remain limited. Hyperuricemia is now recognized as a key driver of hepatic steatosis, inflammation, and fibrosis, with elevated serum uric acid levels independently predicting hepatocellular carcinoma and liver‐related mortality.
Rong Wang, Zhenyu Liu, Jun Lin, Weijing Zhang, Xianzhi Liu, Tong Zhang   +5 more
wiley   +1 more source

Clinical and social aspects of dysmenorrhea development

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2019
Modern antibiotics and synthetic antimicrobial agents play a leading role in the treatment of bacterial infections. Despite their effectiveness, they cause a number of side effects, and thus the search for new antimicrobial and antifungal agents is ...
O. P. Dolhikh, M. I. Romanenko, D. H. Ivanchenko, K. V. Aleksandrova, N. M. Polishchuk   +4 more
doaj   +1 more source

Global Fluoride Toxicology Landscape: Bibliometric Approaches and Scientific Mapping

Environmental Toxicology, EarlyView.
ABSTRACT This study analyzed research trends in the 100 most‐cited articles on fluoride toxicology, a topic widely debated due to the toxic effects associated with levels deemed safe for human exposure. A bibliometric analysis was conducted using the Web of Science‐Core Collection, extracting data such as citation count, authors, keywords, journal ...
Maria Karolina Martins Ferreira, Deiweson Souza‐Monteiro, Priscila Cunha Nascimento, Luciana Eiró‐Quirino, Leonardo Oliveira Bittencourt, Fatemeh Vida Zohoori, Esperanza Angeles Martinez‐Mier, Marilia Afonso Rabelo Buzalaf, Rafael Rodrigues Lima   +8 more
wiley   +1 more source