Results 111 to 120 of about 36,911 (193)

Pomegranate Peel Polyphenol Extract Ameliorates Hyperuricemia by Inhibiting Uric Acid Synthesis and Reabsorption

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
The graphical abstract illustrates the action mechanisms through which PPE alleviates HUA by inhibiting XOD activity, and by suppressing the PI3K‐AKT signaling pathway to downregulate the expression of the urate reabsorption transporters URAT1 and GLUT9, thereby promoting renal UA excretion and attenuating renal injury.
Zeyu Yin, Shufei Liang, Gangao Yang, Pingping Guo, Chao Wang, Qingqing Han, Xinhua Song   +6 more
wiley   +1 more source

Guideline adherence of xanthine oxidase inhibitor utilization to treat gout in primary care. [PDF]

J Manag Care Spec Pharm
Claus LW, Auten ME, Saseen JJ, Billups SJ.   +3 more
europepmc   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, Volume 59, Issue 8, August 2026.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

A universal fluorescent sensing platform based on "signal switching induced by enzyme catalyzed substrate hydrolysis" for high-throughput discovery of xanthine oxidase inhibitors from traditional Chinese medicine. [PDF]

Front Pharmacol
Liu G, Sun K, Lai S, Liu X, Ge Y, Wang P, Wang B, Li Y, Yu XA.   +8 more
europepmc   +1 more source

Clinical Implications and Research Progress of Salivary Biomarkers for Endocrine and Metabolic Disorders

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6561-6575, August 2026.
ABSTRACT Aims Similar to blood, saliva contains a broad range of biomarkers and may offer a non‐invasive, repeatable specimen for endocrine and metabolic assessment. This review aims to synthesise and evaluate recent advances in the clinical translation of salivary biomarkers, while providing a critical assessment of the diagnostic reliability and ...
Chuyan Yu, Jiaying Ni, Qian Dou, Hang Su, Ziyi Zhang, Xiaojing Ma, Qing Dai, Jian Zhou   +7 more
wiley   +1 more source

The changing epidemiology of human type 2 diabetes–associated atherosclerosis: Pathophysiological mechanisms and emerging treatment possibilities

Journal of Internal Medicine, Volume 300, Issue 2, Page 131-152, August 2026.
Abstract Type 2 diabetes (T2D) is a major global health concern strongly associated with atherosclerosis and subsequent macrovascular complications. These complications are the leading cause of death among T2D patients. Despite a decline in cardiovascular events over the last decade, individuals with T2D still have an approximately doubled risk ...
Dania Al‐Sharify, Jiangming Sun, Andreas Edsfeldt   +2 more
wiley   +1 more source

Identification of deferasirox as a human xanthine oxidase inhibitor. [PDF]

Life Med
Qi Y, He X, Wu X, Zhou T, Liang N, Jiao J, Chen Y, Yuan Y, Zhang Y, Wang Y, Liu Y, Ding Q.   +11 more
europepmc   +1 more source

PbrIDD2‐PbrAPX14 Module Functions in the Ethylene‐Mediated Ripening and Senescence Process of Pear Fruit

Plant Biotechnology Journal, Volume 24, Issue 8, Page 4878-4896, August 2026.
ABSTRACT Endogenous H2O2 participated in the ethylene‐dependent ripening and senescence process of horticultural fruit as a secondary messenger; however, the molecular mechanism beneath such a phenomenon has not been fully clarified until recently. By a conjoint analysis of metabolite, enzyme activities, gene expression profiles in AsA‐GSH cycle of ...
Libin Wang, Junpeng Niu, Xiaoyu Tan, Yuhua Xie, Li Jiang, Chen Huan, Xu Zhang, Weiqi Luo, Bing Xie, Xiaopu Ren, Guodong Wang, Yuanyuan Guo, Shaoling Zhang   +12 more
wiley   +1 more source

Gnetumgams A and B: two new 2-phenylbenzofuran derivatives from the lianas of <i>Gnetum montanum</i> with xanthine oxidase inhibitory activity. [PDF]

RSC Adv
Van Do TN, Nguyen MH, Nguyen HX, Nguyen NT, Thi Nguyen MT.   +4 more
europepmc   +1 more source

Long‐Term Salt Exposure Reprograms the Nicotiana tabacum BY‐2 Suspension Proteome and Metabolome Toward Stabilization of the Core Metabolic Pathways, Protein Turnover Machinery Modifications, and Protective Metabolome Adjustments

Plant, Cell &Environment, Volume 49, Issue 8, Page 5849-5865, August 2026.
ABSTRACT In this study, we analyzed a unique Nicotiana tabacum BY‐2 line that was gradually adapted to and subsequently maintained in 190 mM NaCl for over 15 years. Years of continuous high salinity shaped a stable “new homeostasis” in BY‐2 suspension cells. Salt‐adapted cells were smaller and formed tighter clusters. Metabolomics revealed constitutive
Anita Rzadkiewicz, Łukasz Marczak, Aleksander Strugała, Maria Tomys, Ewelina Ratajczak, Tomasz Skrzypczak, Przemysław Wojtaszek, Anna Kasprowicz‐Maluśki, Agnieszka Szuba   +8 more
wiley   +1 more source