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Xanthine oxidase and xanthine dehydrogenase

The FASEB Journal, 1995
Xanthine oxidase and xanthine dehy‐drogenase are enzymes involved in the metabolism of purines and pyrimidines in various organisms. Their relationship to one another has been the subject of considerable debate, primarily because of their proposed roles in ischemia/reperfasion damage in tissues.
Russ Hille, Takeshi Nishino
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Sulfhydryl oxidase-catalyzed conversion of xanthine dehydrogenase to xanthine oxidase

Archives of Biochemistry and Biophysics, 1981
Abstract Xanthine oxidase may be isolated from various mammalian tissues as one of two interconvertible forms, viz., a dehydrogenase (NAD+ dependent, form D) or an oxidase (O2 utilizing, form O). A crude preparation of rat liver xanthine dehydrogenase (form D) was treated with an immobilized preparation of crude bovine sulfhydryl oxidase.
D A, Clare   +3 more
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The reactions of chloroperoxidase in the presence of xanthine/xanthine oxidase

Biochemical and Biophysical Research Communications, 1989
Spectral data are presented which indicate that chloroperoxidase is converted to compound II during the reaction with superoxide/hydrogen peroxide generated in the xanthine/xanthine oxidase system. Upon completion of compound II formation, compound II returns back to the native state of chloroperoxidase without formation of detectable intermediates. It
D, Metodiewa, M, Pickard, H B, Dunford
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Xanthine Oxidase Studies†

Journal of the American Pharmaceutical Association (Scientific ed.), 1952
An investigation was undertaken of the effect on the purine metabolism of the rat of 2-amino-4-hydroxy-6-formyl pteridine, known to inhibit xanthine oxidase, and sodium bromide, reported to retard uricopoiesis. Neither the intraperitoneal administration of the pteridine nor the oral administration of sodium bromide significantly lowered the tissue ...
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Xanthine oxidase

2000
Abstract Xanthine oxidoreductase is widely distributed among mammalian species and is expressed mainly in vascular endothelial cells, hepatocytes, epithelial cells of the intestine, and the secretory cells of the mammary gland. Expression of the enzymatic activity of XO/XD depends on the animal species. XO/XD activity is, for example,
Takaaki Akaike   +2 more
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