Results 161 to 170 of about 37,916 (254)

Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi, Azadeh Niknejad, Elaheh Amini   +2 more
wiley   +1 more source

Inhibition of Xanthine Oxidase by Four Phenolic Acids: Kinetic, Spectroscopic, Molecular Simulation, and Cellular Insights. [PDF]

Foods
Wang X, Su D, Luo X, Chen B, Bhullar KS, Liu H, Wang C, Zhang J, Wang L, Yang H, Zhou W.   +10 more
europepmc   +1 more source

THE RELATIONSHIP OF IRON TO XANTHINE OXIDASE

Journal of Biological Chemistry, 1954
D A, RICHERT, W W, WESTERFELD
openaire   +2 more sources

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Ultrasound-driven antisolvent precipitation for engineered naringenin ultrafine crystals with potent xanthine oxidase inhibitory and bacteriostatic effects. [PDF]

Ultrason Sonochem
Huang Y, Weng C, Zeng F, Dai X, Qiu X, Lin J, Peng B, Zhang X, Liu Z.   +8 more
europepmc   +1 more source

Evaluation of the Phytochemical Composition, Antioxidant Activity, and Enzyme Inhibitory Potential of Salvia heldreichiana Within the Framework of Molecular Docking and CAVER Tunnel Analysis

ChemistryOpen, Volume 15, Issue 6, June 2026.
Methanolic extract of Salvia heldreichiana is characterized by HPLC and GC–MS analyses and evaluated for antioxidant and anti‐Alzheimer activities. Major phenolic compounds are identified, while molecular docking analysis supports the interaction of bioactive constituents with target enzymes, highlighting the therapeutic potential of S.
Erdi Can Aytar, Esin Çolak, Kaan Bedirhan Kahveci, Abidin Gümrükçüoğlu, Süleyman Doğu, Betül Aydın   +5 more
wiley   +1 more source

Influence of xanthine oxidase and inosine monophosphate dehydrogenase polymorphisms on 6-mercaptopurine treatment response in pediatric acute lymphoblastic leukemia. [PDF]

Sci Rep
Sabirova Z, Boucetta MTE, Bensouyad RR, Gagné V, Théorêt Y, Nava T, Leclerc JM, Laverdière C, Sinnett D, Tran TH, Krajinovic M.   +10 more
europepmc   +1 more source

Uric Acid in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Portal Hypertension &Cirrhosis, Volume 5, Issue 2, Page 189-206, June 2026.
MASLD is the most prevalent chronic liver disease worldwide, yet effective pharmacological treatments remain limited. Hyperuricemia is now recognized as a key driver of hepatic steatosis, inflammation, and fibrosis, with elevated serum uric acid levels independently predicting hepatocellular carcinoma and liver‐related mortality.
Rong Wang, Zhenyu Liu, Jun Lin, Weijing Zhang, Xianzhi Liu, Tong Zhang   +5 more
wiley   +1 more source

Unveiling potent xanthine oxidase inhibitors in two Balanophora spp. using machine learning-based virtual screening and molecular docking approach. [PDF]

Sci Rep
An NN, Tung DQ, Van Tue L, Son NT, Tung NT, Le HG, Tam TC, Thuan NT, Baecker D, Dung DTM.   +9 more
europepmc   +1 more source

Morphological and Biochemical Insights Into the Renoprotective Effects of Combined N‐Acetylcysteine and Glycine Treatment in Experimental Diabetic Nephropathy

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Diabetic nephropathy (DN) is a major microvascular complication of diabetes mellitus and the leading cause of end‐stage renal disease. Oxidative stress and inflammation are central drivers of DN progression, yet no effective therapies exist to prevent or delay renal injury. This study investigated the renoprotective effects of glycine (GLY), N‐
Malik Ejubović, Andrej Belančić, Yun Wah Lam, Farideh Javid, Dina Kapić, Esad Ćosović, Rijad Jahić, Orhan Lepara, Amira Jagodić Ejubović, Lejla Alić, Amil Topuz, Zurifa Ajanović, Almir Fajkić   +12 more
wiley   +1 more source