Results 11 to 20 of about 78,843 (311)
Redox Biology, 2023 The conversion of xanthine dehydrogenase (XDH) to xanthine oxidase (XO) occurs only in mammalian species. In fresh bovine milk, the enzyme exists predominantly as the oxidase form, in contrast to various normal organs where it is found primarily as the ...
Teruo Kusano +4 more
doaj +3 more sources
Neurobiology of Disease, 2021 Inflammation and oxidative stress contribute to the pathophysiology of diabetic neuropathy. According to recent evidence, the modulation of macrophage polarization in peripheral nerves represents a potential therapeutic target for diabetic neuropathy ...
Kazuhisa Takahashi +9 more
doaj +1 more source
Molecules, 2023 Dioscoreae hypoglaucae Rhizoma (DH) and Dioscoreae spongiosae Rhizoma (DS) are two similar Chinese herbal medicines derived from the Dioscorea family. DH and DS have been used as medicines in China and other Asian countries for a long time, but study on ...
Guo Rui +6 more
doaj +1 more source
Effect of oxidative stress on the activity of human osteoblastic MG63 cells
口腔疾病防治, 2017 Objective To investigate the morphology and proliferation viability in oxidative stress induced damage in human MG63 cells. Methods The MG63 cells were treated with superoxide anion (O2.⁃) produced by different con⁃ centrations of xanthine/xanthine ...
WANG Qiong
doaj +1 more source
Reductive activation of potential antitumor bis(aziridinyl)benzoquinones by xanthine oxidase: Competition between oxygen reduction and quinone reduction [PDF]
, 1990 The reduction of a series of 2,5-bis(1-aziridinyl)-1,4-benzoquinone (BABQ) derivatives with various 3,6 substituents by the enzyme xanthine oxidase has been studied.
Janssen, L.H.M. +5 more
core +3 more sources
Clinics, 2010 OBJECTIVE: Crimean-Congo hemorrhagic fever is an acute viral hemorrhagic fever with a high mortality rate. Despite increasing knowledge about hemorrhagic fever viruses, little is known about the pathogenesis of Crimean-Congo hemorrhagic fever.
V. Kenan Celik +5 more
doaj +1 more source
Biochemistry Changes That Occur after Death: Potential Markers for Determining Post-Mortem Interval [PDF]
, 2013 Death is likely to result in very extensive biochemical changes in all body tissues due to lack of circulating oxygen, altered enzymatic reactions, cellular degradation, and cessation of anabolic production of metabolites.
Donaldson, Andrea
core +1 more source
Oxidative stress in the pathogenesis of type 1 diabetes: the role of adipocyte xanthine oxidase
Бюллетень сибирской медицины, 2018 Rationale. According to modern understanding, oxidative stress plays an essential role in the underlying mechanisms for the emergence of type 1 and type 2 diabetes and development of complications in these conditions.
V. V. Ivanov +7 more
doaj +1 more source
Xanthine oxidase inhibitors are associated with reduced risk of cardiovascular disease
Scientific Reports, 2021 As previous studies have reported finding an association between hyperuricemia and the development of cardiovascular and chronic kidney disease, hyperuricemia is thought to be an independent risk factor for hypertension and diabetic mellitus. However, we
Hirotaka Saito +10 more
doaj +1 more source
Pharmacology and clinical drug candidates in redox medicine [PDF]
, 2015 SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant ...
Casas, Ana I +11 more
core +3 more sources